Possible involvement of TRP channels in cardiac hypertrophy and arrhythmia.
Possible involvement of TRP channels in cardiac hypertrophy and arrhythmia.
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DOI：
10.2174/1568026611313030006
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发表时间：
2013-01
影响因子：
3.4
通讯作者：
Hiroyuki Watanabe;K. Iino;T. Ohba;Hiroshi Ito
中科院分区：
文献类型：
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作者：
Hiroyuki Watanabe;K. Iino;T. Ohba;Hiroshi Ito
在过去的20年里，瞬时受体电位（TRP）通道的研究显着扩展了我们的知识，关于钙信号在心肌细胞的分子基础。心脏TRP通道的功能意义可能与膜电位的改变或Ca2+进入非收缩室有关，在非收缩室中诱导引起各种心脏疾病的基因表达。本文综述了TRP通道在心脏疾病中的作用。有证据表明：（a）TRPC 1、TRPC 3或TRPC 6活性增加参与心脏肥大的发展，其中这些TRPC通道作为广泛肥大刺激的独特传感器，和（B）TRPM 4突变现在被认为是人类心脏传导障碍的原因。最终，TRP通道可能成为治疗人类心脏疾病的新的药理学靶点。
Over the past 20 years, studies of transient receptor potential (TRP) channels have significantly extended our knowledge regarding the molecular basis of Ca2+ signals in cardiac myocytes. The functional significance of cardiac TRP channels is likely connected to the alteration of membrane potential or Ca2+ entry into a noncontractile compartment, where gene expression responsible for various cardiac diseases is induced. This review highlights some aspects of TRP channels with anticipated roles in cardiac disease. Evidence suggests that (a) increased activities of TRPC1, TRPC3, or TRPC6 are involved in the development of cardiac hypertrophy, where these TRPC channels act as unique sensors for a wide range of hypertrophic stimuli, and (b) mutations in TRPM4 are now recognized as causes of human cardiac conduction disorders. Ultimately, TRP channels may become novel pharmacological targets in the treatment of human cardiac disease.