Tailor-made tricalcium phosphate bone implant directly fabricated by a three-dimensional ink-jet printer.
Tailor-made tricalcium phosphate bone implant directly fabricated by a three-dimensional ink-jet printer.
复制标题
DOI：
10.1007/s10047-006-0347-y
复制
发表时间：
2006-01-01
期刊：
影响因子：
--
通讯作者：
Sasaki, Nobuo
中科院分区：
文献类型：
--
作者：
Igawa, Kazuyo;Mochizuki, Manabu;Sasaki, Nobuo
快速原型制作 (RP) 是一种根据计算机辅助设计 (CAD) 数据构建三维 (3D) 模型的成型技术。我们根据计算机断层扫描 (CT) 数据，使用 RP 喷墨打印机用 α-磷酸三钙粉末制造了新型定制骨植入物 (TI)，并评估了其安全性和有效性。获得7只比格犬头骨的CT数据，并将其转换为CAD数据，在头骨双侧虚拟地形成骨缺损。 TI 的设计是为了适应缺陷，并使用 3D 喷墨打印机制造，具有六个穿过植入物的水平圆柱孔，旨在可能促进血管侵袭和骨再生。作为对照，羟基磷灰石植入物 (HI) 是从多孔羟基磷灰石块上手动切割而成。然后，进行颅骨切除术以制造真正的颅骨缺损，并植入TI和HI。植入后定期进行CT检查，并在24周时对动物实施安乐死。没有观察到重大副作用。 CT分析显示圆柱孔变窄；仅在 TI 中观察到种植体和颞骨之间的骨桥。组织学分析显示，TI 的圆柱形孔内有大量新骨形成，而 HI 的多孔结构主要是结缔组织侵入。仅在 TI 中观察到骨髓。破骨细胞被观察到从圆柱形孔内部吸收再生骨并侵入并可能吸收TI。这些数据表明，TI 是一种安全有效的骨替代物，具有与 HI 相当的骨传导性。
Rapid prototyping (RP) is a molding technique that builds a three-dimensional (3D) model from computer-aided design (CAD) data. We fabricated new tailor-made bone implants (TIs) from alpha-tricalcium phosphate powder using an RP ink-jet printer based on computed tomography (CT) data, and evaluated their safety and efficacy. CT data of the skulls of seven beagle dogs were obtained and converted to CAD data, and bone defects were virtually made in the skull bilaterally. TIs were designed to fit the defects and were fabricated using the 3D ink-jet printer with six horizontal cylindrical holes running through the implants, designed for possible facilitation of vascular invasion and bone regeneration. As a control, hydroxyapatite implants (HIs) were cut manually from porous hydroxyapatite blocks. Then, craniectomy was performed to create real skull defects, and TIs and HIs were implanted. After implantation, CT was performed regularly, and the animals were euthanized at 24 weeks. No major side effects were observed. CT analysis showed narrowing of the cylindrical holes; bony bridging between the implants and the temporal bone was observed only for TIs. Histological analysis revealed substantial new bone formation inside the cylindrical holes in the TIs, while mainly connective tissues invaded the porous structures in HIs. Bone marrow was observed only in TIs. Osteoclasts were seen to resorb regenerated bone from inside the cylindrical holes and to invade and probably resorb the TIs. These data suggest that TIs are a safe and effective bone substitute, possessing osteoconductivity comparable with that of HIs.