Low-cost rapid prototyping of glass microfluidic devices using a micromilling technique
Low-cost rapid prototyping of glass microfluidic devices using a micromilling technique
复制标题
使用微铣削技术对玻璃微流体装置进行低成本快速原型制作
DOI：
10.1007/s10404-018-2104-y
复制
发表时间：
2018-08-01
影响因子：
2.8
通讯作者：
Li, Gang
中科院分区：
文献类型：
--
作者：
Ku, Xiaoyong;Zhang, Zongwei;Li, Gang
提出了一种利用商业微磨机快速制作玻璃微流控装置原型的方法。在所提出的方法中，微铣削与玻璃基板浸泡在冷水中，这可以有效地去除碎片，并增加铣削工具的寿命。我们还研究了主轴转速，进给速度，切削深度，冷却模式和刀具类型对成品通道几何形状，底部表面粗糙度和毛刺沿着通道两侧的影响。结果发现，低切削深度，高主轴转速和低进给速度产生更平滑的通道。几个功能的微流控器件，证明了这种快速成型方法。结果证实，所提出的微铣削技术是一种可行的解决方案，为快速和经济的玻璃基微流控芯片的制造。我们相信这种方法将大大提高玻璃微流控器件对研究人员的可及性。
A method is proposed for rapid prototyping of glass microfluidic devices utilizing a commercial micromilling machine. In the proposed approach, micromilling is performed with the glass substrates immersed in cool water, which could efficiently remove debris and increase the life of milling tools. We also investigate the effects of spindle speed, feed rate, cutting depth, cooling mode, and tool type on finished channel geometries, bottom surface roughness, and burring along the channel sides. It was found that low cutting depths, high spindle speeds and low feed rate produce smoother channels. Several functional microfluidic devices were demonstrated with this rapid prototyping method. The results confirm that the proposed micromilling technique represents a viable solution for the rapid and economic fabrication of glass-based microfluidic chips. We believe that this method will greatly improve the accessibility of glass microfluidic devices to researchers.