Isolation of multipotent adult stem cells from the dermis of mammalian skin
Isolation of multipotent adult stem cells from the dermis of mammalian skin
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DOI：
10.1038/ncb0901-778
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发表时间：
2001-09-01
影响因子：
21.3
通讯作者：
Miller, FD
中科院分区：
文献类型：
--
作者：
Toma, JG;Akhavan, M;Miller, FD
我们在这里描述了从幼年和成年啮齿动物皮肤中分离干细胞。这些细胞来源于真皮，单个细胞的克隆可以在培养中增殖和分化，产生神经元、胶质细胞、平滑肌细胞和脂肪细胞。在分化过程中产生神经元特异性蛋白的类似前体可以从成人头皮中分离出来。由于这些细胞（皮肤来源的前体称为SKPs）产生神经和中胚层后代，我们认为它们代表了一种新的多能成体干细胞，并表明皮肤可能为移植提供一种可获得的自体干细胞来源。
We describe here the isolation of stem cells from juvenile and adult rodent skin. These cells derive from the dermis, and clones of individual cells can proliferate and differentiate in culture to produce neurons, glia, smooth muscle cells and adipocytes. Similar precursors that produce neuron-specific proteins upon differentiation can be isolated from adult human scalp. Because these cells (termed SKPs for skin-derived precursors) generate both neural and mesodermal progeny, we propose that they represent a novel multipotent adult stem cell and suggest that skin may provide an accessible, autologous source of stem cells for transplantation.