Fluorocitrate and neurotropin confer analgesic effects on neuropathic pain in diabetic rats via inhibition of astrocyte activation in the periaqueductal gray
Fluorocitrate and neurotropin confer analgesic effects on neuropathic pain in diabetic rats via inhibition of astrocyte activation in the periaqueductal gray
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DOI：
10.1016/j.neulet.2021.136378
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Zhi Xiao
中科院分区：
文献类型：
--
作者：
Xingfeng Liu;Jingxin He;Jie Gao;Zhi Xiao
Currently, effective treatments for diabetic neuropathic pain (DNP) are still unmet clinical needs. Activation of.astrocytes in the ventrolateral region of periaqueductal gray (vlPAG) has a regulating effect on pain responses..The present study was designed to confrm that repeated intra-vlPAG injection of fluorocitrate (FC), a selective.inhibitor of astrocyte activation or intraperitoneal (IP) injection of neurotropin, a widely prescribed analgesic.drug for chronic pain, inhibited the activation of astrocytes in vlPAG and thus produced an analgesic effect on.DNP. An in vivo model was developed to study DNP in rats. The changes in mechanical withdrawal threshold.(MWT) and activation levels of astrocytes in the vlPAG were evaluated in all experimental rats. Compared with.normal rats, vlPAG-based glial fbrillary acid protein (GFAP) was clearly upregulated, whereas the MWTs of DNP.rats were markedly diminished. The intra-vlPAG injections of FC or IP injections of neurotropin attenuated the.alterations both in MWTs and expression levels of GFAP in vlPAG in DNP rats. Collectively, these fndings suggest.the antinociceptive effects of FC and neurotropin in DNP rats, which were associated with suppressing the.activation of astrocytes in vlPAG.
