Assessment of porcine endogenous retrovirus transmission across an alginate barrier used for the encapsulation of porcine islets
Assessment of porcine endogenous retrovirus transmission across an alginate barrier used for the encapsulation of porcine islets
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DOI：
10.1111/xen.12409
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发表时间：
2018-11
影响因子：
3.9
通讯作者：
C. Crossan;N. Mourad;Karen Smith;P. Gianello;L. Scobie
中科院分区：
文献类型：
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作者：
C. Crossan;N. Mourad;Karen Smith;P. Gianello;L. Scobie
Subcutaneous implantation of a macroencapsulated patch containing human allogenic islets has been successfully used to alleviate type 1 diabetes mellitus (T1DM) in a human recipient without the need for immunosuppression. The use of encapsulated porcine islets to treat T1DM has also been reported. Although no evidence of pathogen transfer using this technology has been reported to date, we deemed it appropriate to determine if the encapsulation technology would prevent the release of virus, in particular, the porcine endogenous retrovirus (PERV).
