Iron treatment normalizes cognitive functioning in young women
Iron treatment normalizes cognitive functioning in young women
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DOI：
10.1093/ajcn/85.3.778
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发表时间：
2007-03-01
影响因子：
7.1
通讯作者：
Beard, John L.
中科院分区：
文献类型：
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作者：
Murray-Kolb, Laura E.;Beard, John L.
背景：有证据表明，在生命中的任何时候，脑铁缺乏都可能破坏代谢过程，从而改变认知和行为功能。育龄妇女是最容易缺铁的人群之一，可能因缺铁而发生认知改变的风险很高。目的：探讨年轻女性铁含量与认知能力的关系。设计：一项盲法、安慰剂对照、分层干预研究在18-35岁不同铁状态的女性中进行，这些女性被随机分配接受铁补充剂或安慰剂。在基线（n = 149）和治疗16周（n = 113）后，通过8项认知表现任务（来自Detterman认知能力测试）评估认知能力。结果：在基线时，铁充足的女性（n = 42）比缺铁性贫血的女性（n = 34）在认知任务上表现更好（P = 0.011），完成任务的速度也更快（P = 0.038）。缺铁但未贫血的女性（n = 73）表现准确性和完成任务所需时间的因素介于铁状态的两个极端之间。治疗后，血清铁蛋白的显著改善与认知表现的5-7倍改善有关，而血红蛋白的显著改善与完成认知任务的速度提高有关。结论：铁含量是影响育龄妇女认知能力的重要因素。贫血的严重程度主要影响处理速度，铁缺乏的严重程度影响认知功能在广泛任务中的准确性。因此，缺铁对认知的影响并不局限于发育中的大脑。
Background: Evidence suggests that brain iron deficiency at any time in life may disrupt metabolic processes and subsequently change cognitive and behavioral functioning. Women of reproductive age are among those most vulnerable to iron deficiency and may be at high risk for cognitive alterations due to iron deficiency.Objective: We aimed to examine the relation between iron status and cognitive abilities in young women.Design: A blinded, placebo-controlled, stratified intervention study was conducted in women aged 18-35 y of varied iron status who were randomly assigned to receive iron supplements or a placebo. Cognition was assessed by using 8 cognitive performance tasks (from Detterman's Cognitive Abilities Test) at baseline (n = 149) and after 16 wk of treatment (n = 113).Results: At baseline, the iron-sufficient women (n = 42) performed better on cognitive tasks (P = 0.011) and completed them faster (P = 0.038) than did the women with iron deficiency anemia (n 34). Factors representing performance accuracy and the time needed to complete the tasks by the iron-deficient but nonanemic women (n = 73) were intermediate between the 2 extremes of iron status. After treatment, a significant improvement in serum ferritin was associated with a 5-7-fold improvement in cognitive performance, whereas a significant improvement in hemoglobin was related to improved speed in completing the cognitive tasks.Conclusions: Iron status is a significant factor in cognitive performance in women of reproductive age. Severity of anemia primarily affects processing speed, and severity of iron deficiency affects accuracy of cognitive function over a broad range of tasks. Thus, the effects of iron deficiency on cognition are not limited to the developing brain.