An essential role for TAK1 in the contact hypersensitivity response.
An essential role for TAK1 in the contact hypersensitivity response.
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DOI：
10.1038/cmi.2011.11
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发表时间：
2011-07
影响因子：
24.1
通讯作者：
中科院分区：
文献类型：
--
作者：
Contact hypersensitivity (CHS) is a delayed-type-hypersensitivity that can be induced by haptens, such as 2,4-dinitrofluorobenzene (DNFB). Innate and adaptive immunity are both important for CHS development. To treat CHS related disease, such as allergic contact dermatitis (ACD) prevalent in industrialized countries, ways to interfere with immune function during CHS response need to be identified. Transforming growth factor-β activated kinase-1 (TAK1), a member of mitogen-activated protein kinase kinase kinase (MAPKKK) family, is important for both innate and adaptive immunity. We thus hypothesized that CHS response could be inhibited by interfering with TAK1 activity. Using a mouse model where TAK1 deletion can be locally induced, we observed that TAK deficiency led to impaired CHS response associating with defective T cell expansion, activation and IFN-γ production. In addition, we investigated the effect of TAK1 deletion specifically in dendritic cells (DC) on CHS response. We found that, when TAK1 is deficient in DC, CHS response was abolished and hapten elicited T cell response was defective. Collectively, this study demonstrates an essential role of TAK1 in the induction of CHS and suggests that targeting TAK1 could be a viable approach to treat CHS.
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影响因子：
30.5
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通讯作者：
Akira, S
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Weltzien, HU
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通讯作者：
Freudenberg, Marina A.
影响因子：
3.8
作者：
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通讯作者：
Ridder, GM