Aggregation-Induced Emission Luminogens Married to 2D Black Phosphorus Nanosheets for Highly Efficient Multimodal Theranostics
Aggregation-Induced Emission Luminogens Married to 2D Black Phosphorus Nanosheets for Highly Efficient Multimodal Theranostics
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聚集诱导发射发光剂与二维黑磷纳米片结合，实现高效多模式治疗诊断
DOI：
10.1002/adma.202003382
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发表时间：
2020-08-06
影响因子：
29.4
通讯作者：
Tang, Ben Zhong
中科院分区：
文献类型：
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作者：
Huang, Jiachang;He, Benzhao;Tang, Ben Zhong
受聚集诱导发射（AIE）活性光敏剂和黑磷纳米材料在癌症治疗中各自优势的启发，展示了与二维黑磷纳米片结合的新型 AIE 光敏剂的简便构建及其在多模式治疗诊断中的应用。所开发的纳米材料同时具有独特的性质和多种功能，包括优异的稳定性、良好的生物相容性、近红外区域的强荧光发射、高性能的活性氧生成、良好的光热转换效率、出色的细胞摄取以及在肿瘤部位的有效积累。体外和体内评估均表明，所提出的纳米治疗系统是近红外荧光-光热双成像引导的协同光动力-光热疗法的优秀候选者。因此，这项研究不仅扩展了AIE和黑磷材料的应用范围，而且为设计新一代癌症治疗方案的潜在临床应用提供了有用的见解。
Inspired by the respective advantages of aggregation-induced emission (AIE)-active photosensitizers and black phosphorus nanomaterials in cancer treatment, the facile construction of novel AIE photosensitizers married to 2D black phosphorus nanosheets and their application for multimodal theranostics are demonstrated. The developed nanomaterial simultaneously possesses distinctive properties and multiple functions including excellent stability, good biocompatibility, intensive fluorescence emission in the NIR region, high-performance reactive oxygen species generation, good photothermal conversion efficiency, outstanding cellular uptake, and effective accumulation at the tumor site. Both in vitro and in vivo evaluation show that the presented nanotheranostic system is an excellent candidate for NIR fluorescence-photothermal dual imaging-guided synergistic photodynamic-photothermal therapies. This study thus not only extends the applications scope of AIE and black phosphorus materials, but also offers useful insights into designing a new generation of cancer theranostic protocol for potential clinical applications.