Daily Habit of Water Intake in Patients with Cerebral Infarction before its Onset; Comparison with a Healthy Population: A Cross-sectional Study
Daily Habit of Water Intake in Patients with Cerebral Infarction before its Onset; Comparison with a Healthy Population: A Cross-sectional Study
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脑梗塞患者发病前每日饮水习惯分析
DOI：
10.1159/000500075
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发表时间：
2019
影响因子：
2.9
通讯作者：
Daisuke Sugiyama and Tomonori Okamura
中科院分区：
文献类型：
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作者：
Tomofumi Nishikawa;Naomi Miyamatsu;Aya Higashiyama;Masato Hojo;Yoko Nishida;Shunichi Fukuda;Takumi Hirata;Kayoko Ichiura;Yoshimi Kubota;Sachimi Kubo;Tetsuya Ueba;Aya Kadota;Daisuke Sugiyama and Tomonori Okamura
背景：虽然水的摄入量是经常建议，以防止脑梗死（CI），只有少数研究已经发表在此topic.Objectives：本研究回顾性估计每日非酒精饮料（NAD）的摄入量在CI患者CI发病前，并将其与NAD在健康subjects.Methods：我们进行了一项横断面研究，CI患者在3家医院和健康受试者的科比骨科和生物医学流行病学（KOBE）研究。分析使用了1，287名受试者（274名CI患者和1，013名健康受试者）的数据。通过将CI患者根据其当前NAD摄入量分为“增加”、“不变”和“减少”组，我们通过协方差分析和事后检验，调整性别、年龄、调查月份、体重指数、饮酒史和吸烟史，比较了这3组与健康受试者之间的NAD摄入量。假设“未改变”组的NAD摄入量等于CI发作前的NAD摄入量，计算“未改变”组和健康受试者中调整相关变量后的CI较少NAD摄入量的OR;使用Youden指数选择截止点。结果：参与者的平均年龄（平均值± SD）为62.8 ± 9.3岁。151名患者（36名女性）被纳入“增加”组; 105名（30名女性）被纳入“不变”组; 18名（2名女性）被纳入“减少”组; 1,013名（706名女性）被纳入“健康”组。“增加”组的平均NAD摄入量为1，702.5 ± 670.2 mL，“不变”组为1，494.2 ± 611.2 mL，“减少”组为1，268.0 ± 596.1 mL，“健康”组为1，720.6 ± 686.0 mL。调整相关变量后，观察到两组间NAD摄入量存在显著差异（F = 6.1，p < 0.001），事后检验表明“健康”组和“未改变”组之间以及“增加”组和“未改变”组之间NAD摄入量存在显著差异（p< 0.05）。NAD摄入量低于1, 570 mL/d（采用Youden指数）对CI的OR值为2.48（95%CI1.52 -4.07）。结论：脑梗死患者发病前每日NAD摄入量低于健康人，提示充足的NAD摄入对脑梗死有保护作用。
Background:While water intake is frequently recommended to prevent cerebral infarction (CI), only few studies have been published on this topic.Objectives:This study retrospectively estimated the daily non-alcohol drink (NAD) intake in CI patients before CI onset and compared it with NAD in healthy subjects.Methods:We performed a cross-sectional study on CI patients in 3 hospitals and healthy subjects in the Kobe Orthopedic and Biomedical Epidemiologic (KOBE) study. Data from 1,287 subjects (274 CI patients and 1,013 healthy subjects) were used for the analyses. By dividing the CI patients into “increased”, “unchanged”, and “decreased” groups according to their current NAD intake, we compared the NAD intake between these 3 groups and healthy subjects by analyses of covariance and the post hoc test, adjusting for sex, age, surveyed month, body mass index, alcohol drinking history, and smoking history. Under the assumption that the NAD intake in the “unchanged” group was equal to the NAD intake before CI onset, the OR of less NAD intake for CI adjusting for the relevant variables in the “unchanged” group and the healthy subjects was calculated; the cut-off point was chosen using Youden’s index.Results:The mean age (mean ± SD) of the participants was 62.8 ± 9.3 years. One hundred and fifty-one patients (36 women) were included in the “increased” group; 105 (30 women), in the “unchanged” group; 18 (2 women), in the “decreased” group; and 1,013 (706 women), in the “healthy” group. The mean NAD intake was 1,702.5 ± 670.2 mL in the “increased” group, 1,494.2 ± 611.2 mL in the “unchanged” group, 1,268.0 ± 596.1 mL in the “decreased” group, and 1,720.6 ± 686.0 mL in the “healthy” group. After adjusting for the relevant variables, a significant difference in NAD intake between the groups was observed (F = 6.1,p< 0.001), and a post hoc test demonstrated significant differences (p< 0.05) in NAD intake between the “healthy” and “unchanged” groups, and between the “increased” and “unchanged” groups. The OR of less NAD intake (<1,570 mL/day, chosen using Youden’s index) for CI was 2.48 (95% CI 1.52–4.07).Conclusion:This study showed that daily NAD intake before CI onset in CI patients was less than that in healthy persons, indicating that sufficient intake of NAD may be protective for CI.