Treatment of blastomycosis with higher doses of fluconazole. The National Institute of Allergy and Infectious Diseases Mycoses Study Group.
Treatment of blastomycosis with higher doses of fluconazole. The National Institute of Allergy and Infectious Diseases Mycoses Study Group.
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用较高剂量的氟康唑治疗芽生菌病。
DOI：
10.1086/514539
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
Dismukes,WE
中科院分区：
文献类型：
--
作者：
Pappas,PG;Bradsher,RW;Kauffman,CA;Cloud,GA;Thomas,CJ;CampbellJr,GD;Chapman,SW;Newman,C;Dismukes,WE
最近的临床数据表明，氟康唑每日剂量为200至400毫克，至少6个月是中度有效的治疗非危及生命的芽生菌病。为了研究更高剂量的氟康唑治疗这种疾病的有效性，我们进行了一项多中心，随机，开放标签研究，以确定两种不同的每日剂量的氟康唑（400和800毫克）治疗非危及生命的芽生菌病的疗效和安全性。在39例可评价疗效分析的患者中，34例（87%）成功治疗，分别包括89%和85%接受400和800 mg治疗的患者。既往抗真菌治疗失败的6例患者中有5例（83%）成功治疗。成功治疗患者的平均治疗持续时间为8.9个月。19名患者（48%）报告了不良事件，尽管大多数是轻微的。我们的结论是，氟康唑在400至800毫克的每日剂量至少6个月是有效的治疗非危及生命的芽生菌病。
Recent clinical data suggest that fluconazole at daily doses of 200 to 400 mg for at least 6 months is moderately effective therapy for non-life-threatening blastomycosis. To examine the usefulness of higher doses of fluconazole therapy for this disorder, we conducted a multicenter, randomized, open-label study to determine the efficacy and safety of two different daily doses of fluconazole (400 and 800 mg) in the treatment of non-life-threatening blastomycosis. Of 39 patients evaluable for efficacy analysis, 34 (87%) were successfully treated, including 89% and 85% of patients who received 400 and 800 mg, respectively. Five (83%) of six patients for whom prior antifungal therapy had failed were successfully treated. The mean duration of therapy was 8.9 months for successfully treated patients. Nineteen patients (48%) reported adverse events, although most were minor. We conclude that fluconazole at daily doses of 400 to 800 mg for at least 6 months is effective therapy for non-life-threatening blastomycosis.