Full-Length Genome Characterization of a Novel Simian Immunodeficiency Virus Lineage (SIVolc) from Olive Colobus (Procolobus verus) and New SIVwrcPbb Strains from Western Red Colobus (Piliocolobus badius badius) from the Tai Forest in Ivory Coast
Full-Length Genome Characterization of a Novel Simian Immunodeficiency Virus Lineage (SIVolc) from Olive Colobus (Procolobus verus) and New SIVwrcPbb Strains from Western Red Colobus (Piliocolobus badius badius) from the Tai Forest in Ivory Coast
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DOI：
10.1128/jvi.01725-08
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发表时间：
2009-01-01
影响因子：
5.4
通讯作者：
Peeters, Martine
中科院分区：
文献类型：
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作者：
Liegeois, Florian;Lafay, Benedicte;Peeters, Martine
在大量非洲灵长类动物中发现了猿猴免疫缺陷病毒（SIV），人类通过狩猎和处理灵长类动物的肉继续暴露于这些病毒。全长基因组序列从来自居住在象牙海岸Tai森林的两种Colobinae物种的SIV获得，每种属于不同的属：来自西部红疣猴（Piliocolobus badius badius）的SIVwrc（SIVwrcPbb-98 CI 04和SIVwrcPbb-97 CI 14）和来自橄榄疣猴（Procolobus verus）的SIVolc（SIVolc-97 CI 12）。系统发育分析表明，西部红疣猴是SIVwrc的天然宿主，SIVolc也是一个独特的物种特异性谱系，尽管在其整个基因组长度上与SIVwrc谱系有较远的关系。总的来说，SIVwrc和SIVolc两者在整个基因组中也与SIVlho/sun谱系远缘相关。与感染猕猴属成员的SIV组（SIVsyk、SIVdeb、SIVden、SIVgsn、SIVmus和SIVmon）相似，来自西部红疣猴和橄榄疣猴、L 'Hoest和长尾猴的SIV以及来自山鸡的SIVmnd-1形成了第二组病毒，在系统发育树中始终聚在一起。有趣的是，不同的SIVcol谱系，从mantled guereza（Colobus guereza）在喀麦隆，也密切相关的SIVwrc，SIVolc，和SIVlho/太阳谱系在5'部分的波尔。总体而言，这些结果表明这些不同的慢病毒之间的祖先联系，并再次强调了灵长类慢病毒的自然历史和进化的复杂性。
Simian immunodeficiency viruses (SIVs) are found in an extensive number of African primates and humans continue to be exposed to these viruses by hunting and handling of primate bushmeat. Full-length genome sequences were obtained from SIVs derived from two Colobinae species inhabiting the Tai forest, Ivory Coast, each belonging to a different genus: SIVwrc from western red colobus (Piliocolobus badius badius) (SIVwrcPbb-98CI04 and SIVwrcPbb-97CI14) and SIVolc (SIVolc-97CI12) from olive colobus (Procolobus verus). Phylogenetic analysis showed that western red colobus are the natural hosts of SIVwrc, and SIVolc is also a distinct species-specific lineage, although distantly related to the SIVwrc lineage across the entire length of its genome. Overall, both SIVwrc and SIVolc, are also distantly related to the SIVlho/sun lineage across the whole genome. Similar to the group of SIVs (SIVsyk, SIVdeb, SIVden, SIVgsn, SIVmus, and SIVmon) infecting members of the Cercopithecus genus, SIVs derived from western red and olive colobus, L'Hoest and suntailed monkeys, and SIVmnd-1 from mandrills form a second group of viruses that cluster consistently together in phylogenetic trees. Interestingly, the divergent SIVcol lineage, from mantled guerezas (Colobus guereza) in Cameroon, is also closely related to SIVwrc, SIVolc, and the SIVlho/sun lineage in the 5' part of Pol. Overall, these results suggest an ancestral link between these different lentiviruses and highlight once more the complexity of the natural history and evolution of primate lentiviruses.