A study on negative and depressive symptom prevalence in individuals at ultra-high risk for psychosis
A study on negative and depressive symptom prevalence in individuals at ultra-high risk for psychosis
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DOI：
10.1111/eip.12386
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发表时间：
2018-10-01
影响因子：
2
通讯作者：
Lepage, Martin
中科院分区：
文献类型：
--
作者：
Azar, Marleine;Pruessner, Marita;Lepage, Martin
背景精神病性障碍前驱期存在阴性症状，但其患病率尚不清楚。在超高风险（UHR）人群中检查阴性症状的研究显示出一些局限性，特别是未能控制抑郁症。本研究的目的是检查的患病率的阴性症状的抑郁症的存在下，在没有这样的症状（主要阴性症状）超过1年，并检查在精神病转换器和non-converter.MethodsParticipants的阴性症状的差异在UHR的123个人的精神病的发展接受后续为期2年。阴性症状和抑郁症进行了测量，在基线，6和12个月后admission.ResultsAt基线，阴性症状和主要阴性症状的患病率分别为76.4%和32.7%，阴性症状的评估量表和蒙哥马利-阿斯伯格抑郁量表。尽管阴性症状的患病率在6个月时显著降低，但原发性阴性症状的患病率在所有时间点均相似。阴性症状在基线没有不同的后期转换器和非转换器psycho.ConclusionOur的研究结果证实存在的继发性和原发性阴性症状在UHR的个人，但建议随着时间的推移，这两个措施的差异轨迹。未来的研究应包括更大的UHR组，并侧重于调查随着时间的推移，主要阴性症状的个体内变化，并进一步探讨其对精神病转换的潜在作用。
BackgroundNegative symptoms are known to be present in the prodromal stage of psychotic disorders, yet little is known about their prevalence. Studies examining the presence of negative symptoms in ultra-high risk (UHR) populations have shown some limitations, notably failing to control depression. The objective of this study was to examine the prevalence of negative symptoms in the presence of significant levels of depression and in the absence of such symptoms (primary negative symptoms) over 1 year and to examine differences in negative symptoms in psychosis converters and non-converters.MethodsParticipants were 123 individuals at UHR for the development of psychosis receiving follow-up for a period of 2 years. Negative symptoms and depression were measured using the Scale for the Assessment of Negative Symptoms and the Montgomery-Asberg Depression Scale at baseline, 6 and 12 months post-admission.ResultsAt baseline, the prevalence of negative symptoms and primary negative symptoms was 76.4% and 32.7%, respectively. Whereas the prevalence of negative symptoms was significantly decreased at 6 months, the prevalence of primary negative symptoms was similar at all time points. Negative symptoms at baseline were not different between later converters and non-converters to psychosis.ConclusionOur findings confirm the presence of secondary and primary negative symptoms in individuals at UHR, but suggest a differential trajectory of both measures over time. Future studies should include larger UHR groups and focus on the investigation of intra-individual changes in primary negative symptoms over time and further explore their potential role for psychosis conversion.