Membrane-Integrated Glass Capillary Device for Preparing Small-Sized Water-in-Oil-in-Water Emulsion Droplets
Membrane-Integrated Glass Capillary Device for Preparing Small-Sized Water-in-Oil-in-Water Emulsion Droplets
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DOI：
10.1021/acs.langmuir.5b01514
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发表时间：
2015-06-30
期刊：
影响因子：
3.9
通讯作者：
Weitz, David A.
中科院分区：
文献类型：
--
作者：
Akamatsu, Kazuki;Kanasugi, Shosuke;Weitz, David A.
在这项研究中，展示了一种用于制备小尺寸水包油包水（W/O/W）乳液液滴的膜集成玻璃毛细管装置。将微流控技术与膜乳化技术相结合制备精确结构控制的双乳液液滴的概念为制备小尺寸、结构控制的双乳液液滴提供了一种简单的方法。该集成装置最重要的特点是当毛细管处产生的乳液液滴通过膜时能够减小液滴尺寸。同时，大部分油壳层被剥离，所得双乳化液滴具有薄壳层。还表明，所得双乳液液滴的尺寸很大程度上受到双乳液液滴通过膜的通量和膜孔径的影响；当通量增加、膜孔位减少时，生成的W/O/W乳液液滴比原来更小。使用高速相机对W/O/W乳液液滴穿过膜的渗透行为进行原位观察，证明了（1）中间油相的剥离，（2）双乳液液滴的分裂产生两个或更多个较小尺寸的液滴，以及（3）双乳液液滴的崩溃。第一种现象导致油壳变薄，第二种现象产生比原来更小的双乳化液滴。
In this study, a membrane-integrated glass capillary device for preparing small-sized water-in-oil-in-water (W/O/W) emulsion droplets is demonstrated. The concept of integrating microfluidics to prepare precise structure-controlled double emulsion droplets with the membrane emulsification technique provides a simple method for preparing small-sized and structure-controlled double emulsion droplets. The most important feature of the integrated device is the ability to decrease droplet Size when the emulsion droplets generated at the capillary pass through the membrane. At the same time, most of the oil shell layer is stripped away and the resultant double emulsion droplets have thin Shell's. It is also demonstrated that the sizes of the resultant double emulsion droplets are greatly affected by both the double emulsion droplet flux through membranes and membrane pore size; when the flux is increased and membrane pore site is decreased, the generated W/O/W emulsion droplets are smaller than the original. In situ observation Of the permeation behavior of the W/O/W emulsion droplets through membranes using a high-speed camera demonstrates (1) the stripping of the middle oil phase, (2) the division of the double emulsion droplets to generate two or more droplets with smaller Size, and (3) the collapse of the double emulsion droplets. The first phenomenon results in a thinner oil shell, and the second division phenomenon produces double emulsion droplets that are smaller than the original.