Engineered growth factors and cutaneous wound healing: Success and possible questions in the past 10 years
Engineered growth factors and cutaneous wound healing: Success and possible questions in the past 10 years
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DOI：
10.1111/j.1067-1927.2005.130202.x
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发表时间：
2005-03-01
影响因子：
2.9
通讯作者：
Sheng, ZY
中科院分区：
文献类型：
--
作者：
Fu, XB;Li, XK;Sheng, ZY
在过去的10年里，包括重组人表皮生长因子、碱性成纤维细胞生长因子和血小板衍生生长因子在内的许多工程化生长因子已经被生产出来并应用于临床。在对不同中心的结果进行筛选后，发现一些结果是令人鼓舞的，而另一些结果则令人沮丧。尽管对这些结果的解读可能取决于你的视角，但它也可能取决于不同的标准、不同的创伤，甚至不同的目标。本文就生长因子的应用和皮肤创面愈合的成功经验和失败作一综述。根据这些信息和我们的临床经验，我们解决了人们的担忧，如生长因子到目前为止是否改变了临床实践，生长因子治疗是否解决了伤口愈合中的所有问题。急、慢性创面是否需要外源性应用生长因子？如果需要，使用生长因子促进创面愈合安全吗？最后，在用生长因子治疗的伤口中，我们能达到完美的伤口愈合吗？
In the past 10 years, many engineered growth factors, including recombinant human epidermal growth factor, basic fibroblast growth factor, and platelet-derived growth factor, have been produced and used in the clinic. After screening the results from different centers, some results are found to be encouraging, while others are discouraging. Although the interpretation of these results may depend on your perspective, it may also depend on different criteria, different wounds, and even different aims. In this article, successful experiences and failures concerning the use of growth factors and cutaneous wound healing are summarized. Based on this information and our clinical experience, we address people's concerns such as whether growth factors have altered clinical practice thus far and whether growth factor treatments have solved all problems involved in wound healing. Is there a need for exogenous application of growth factors in acute or chronic wounds, and if so, is it safe to use growth factors to promote wound healing? Last, can we achieve perfect wound healing in those wounds treated with growth factors?