Time-varied magnetic field enhances transport of magnetic nanoparticles in viscous gel
Time-varied magnetic field enhances transport of magnetic nanoparticles in viscous gel
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DOI：
10.2217/nnm.09.97
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发表时间：
2010-01-01
期刊：
影响因子：
5.5
通讯作者：
Polyak, Boris
中科院分区：
文献类型：
--
作者：
MacDonald, Cristin;Friedman, Gary;Polyak, Boris
目的：磁性纳米颗粒(MNPs)用于多种治疗的潜力尚未完全实现，部分原因是难以将载体通过软组织输送到不同的靶点。这项研究的目的是证明MNPs在粘性凝胶中的传输可以由AC(时变)磁场和静电场梯度相结合来控制。材料和方法：在不同磁场和磁铁负载的条件下，测量粘性凝胶中的MNP速度和转运效率。结果：与静磁场梯度相结合，30%(w/w)的磁铁矿颗粒在粘性凝胶中的转运效率是静电场条件下的近30倍。结论：交流磁场的“振荡”效应通过降低凝胶的有效粘度，极大地提高了MNPs在软介质中的传输能力。
Aim: The potential of magnetic nanoparticles (MNPs) to deliver various forms of therapy has not been fully realized, in part due to difficulties in transporting the carriers through soft tissue to different target sites. The aim of this study was to demonstrate that transport of MNPs through a viscous gel can be controlled by a combined AC (time-varying) magnetic field and static field gradient. Materials & methods: MNP velocity and transport efficiency were measured in a viscous gel at various settings of magnetic field and magnetite loadings. Results: Combined application of an AC magnetic field with the static field gradient resulted in a nearly 30-fold increase in MNP transport efficiency in viscous gel for 30% (w/w) magnetite-loaded particles as compared with static field conditions. Conclusion: The 'oscillating' effect of an AC magnetic field greatly improves the ability to transport MNPs within soft media by decreasing the effective viscosity of the gel.