Sol-gel synthesis and characterisation of nano-sized hydroxyapatite powders and hydroxyapatite/poly(D,L-lactide-co-glycolide) composite scaffolds
Sol-gel synthesis and characterisation of nano-sized hydroxyapatite powders and hydroxyapatite/poly(D,L-lactide-co-glycolide) composite scaffolds
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DOI：
10.1177/096739110701500207
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发表时间：
2007-01-01
影响因子：
2.1
通讯作者：
Zhou, Xinyu
中科院分区：
文献类型：
--
作者：
Gu, Shuying;Zhan, Hui;Zhou, Xinyu
以硝酸钙、Ca（NO3）（2）中心点、4 H（2）O和五氧化二磷为原料，采用溶胶-凝胶法制备了纳米羟基磷灰石（NHA）粉体。采用热重/差示扫描量热法、X射线衍射-傅立叶变换-红外光谱、激光粒度分析和透射电镜等分析手段，研究了工艺参数对羟基磷灰石粉体组成、粒度和形貌的影响。HA凝胶经600 ℃煅烧后，可得到粒径为30-100 nm的高纯HA粉末。粒度分布较窄，在600 ℃下颗粒分散良好。采用热致相分离法制备了羟基磷灰石/聚（D，L-丙交酯-乙交酯）（NHA/PLGA）复合支架。研究了支架的抗压强度和吸水率。NHA的加入显著提高了复合材料的力学强度，的NHA具有良好的力学性能，平均压缩强度为2.53 MPa。NHA/PLGA复合材料的亲水性也随着NHA的加入而增强，可作为组织工程支架材料的候选材料。
Nano-sized hydroxyapatite (NHA) powders were prepared from calcium nitrate Ca(NO3)(2) center dot 4H(2)O and phosphorus pentoxide using a sol-gel approach. The effects of processing parameters on the composition granularity, and morphologies of hydroxyapatite powders were investigated by thermo-gravimetry/differential scanning calorimetry, X-ray diffraction Fourier Transform-infrared spectroscopy, laser particle analysis and transmission electron microscopy. High purity HA powders with particle size of 30-100 nm were obtained by calcining HA gel at 600 degrees C. The granularity had a narrow distribution and the particles were dispersed well at 600 degrees C. Hydroxyapatite/poly(D,L-lactide-co-glycolide) (NHA/PLGA) composite scaffolds were prepared by thermally induced phase separation. The compressive strength and water absorption of the scaffolds were investigated. Their mechanical strength increased significantly with the addition of NHA.The composites with 25 wt.% of NHA exhibited good mechanical properties with an average compressive strength of 2.53 MPa. The hydrophilicity increased with the addition of NHA too.NHA/PLGA scaffolds could be a candidate for tissue engineering.