Treadmill Running in Established Phase Arthritis Inhibits Joint Destruction in Rat Rheumatoid Arthritis Models
Treadmill Running in Established Phase Arthritis Inhibits Joint Destruction in Rat Rheumatoid Arthritis Models
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DOI：
10.3390/ijms20205100
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发表时间：
2019-10-02
影响因子：
5.6
通讯作者：
Mikami, Yasuo
中科院分区：
文献类型：
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作者：
Fujii, Yuta;Inoue, Hiroaki;Mikami, Yasuo
运动疗法通过抑制促炎细胞因子来抑制关节破坏。药物治疗类风湿性关节炎的疗效因疾病的阶段而异，但运动疗法对每个阶段的疗效尚不清楚。我们使用大鼠类风湿性关节炎模型，评估了不同阶段跑步机跑步对类风湿性关节炎疗效的差异。以胶原诱导性关节炎大鼠为类风湿关节炎模型，免疫后分为关节炎前期和建立期。在组织学上，与其他组相比，在建立阶段进行强迫跑台运动的组显著抑制了关节破坏。仅在建立阶段进行强制跑台运动的组与未进行跑台运动的组相比，骨形态计量学显著更好，滑膜中连接蛋白43和肿瘤坏死因子α的表达减少。此外，在建立阶段的强制跑台运动组中，组织蛋白酶K免疫染色阳性细胞很少。我们的研究结果表明，运动疗法的疗效可能会有所不同，这取决于类风湿性关节炎疾病的活动。在疾病活动减少的阶段积极锻炼可以有效地抑制关节炎和关节破坏。
Exercise therapy inhibits joint destruction by suppressing pro-inflammatory cytokines. The efficacy of pharmacotherapy for rheumatoid arthritis differs depending on the phase of the disease, but that of exercise therapy for each phase is unknown. We assessed the differences in the efficacy of treadmill running on rheumatoid arthritis at various phases, using rat rheumatoid arthritis models. Rats with collagen-induced arthritis were used as rheumatoid arthritis models, and the phase after immunization was divided as pre-arthritis and established phases. Histologically, the groups with forced treadmill running in the established phase had significantly inhibited joint destruction compared with the other groups. The group with forced treadmill running in only the established phase had significantly better bone morphometry and reduced expression of connexin 43 and tumor necrosis factor alpha in the synovial membranes compared with the no treadmill group. Furthermore, few cells were positive for cathepsin K immunostaining in the groups with forced treadmill running in the established phase. Our results suggest that the efficacy of exercise therapy may differ depending on rheumatoid arthritis disease activity. Active exercise during phases of decreased disease activity may effectively inhibit arthritis and joint destruction.