Novel therapeutic targets of tumor metabolism.
Novel therapeutic targets of tumor metabolism.
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DOI：
10.1097/ppo.0000000000000099
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发表时间：
2015-03
期刊：
影响因子：
--
通讯作者：
Rathmell JC
中科院分区：
文献类型：
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作者：
Kishton RJ;Rathmell JC
对肿瘤代谢的研究使人们对癌细胞如何改变控制细胞能量学的代谢途径以增加增殖和存活有了新的认识。肿瘤细胞已显示出改变参与葡萄糖、谷氨酰胺和线粒体代谢的代谢途径，以产生快速细胞增殖所需的原料，维持有利的细胞氧化还原环境，改变细胞表观遗传学，甚至促进和维持致癌转化。因此，针对肿瘤细胞通常采用的用于治疗目的的代谢改变一直存在强烈的科学和临床兴趣。在这篇综述中，我们描述了常见的肿瘤细胞中的代谢改变，并讨论了如何将这些改变作为临床前和临床环境中药物干预的潜在靶点进行研究。我们还讨论了一些与使用肿瘤代谢作为癌症治疗中的治疗靶点相关的挑战，沿着克服这些挑战的潜在途径。
The study of tumor metabolism has resulted in new understandings of how cancer cells modify metabolic pathways that control cellular energetics to allow increased proliferation and survival. Tumor cells have been shown to alter metabolic pathways involved in glucose, glutamine and mitochondrial metabolism to generate raw materials needed for rapid cellular proliferation, maintain favorable cellular redox environments, modify cellular epigenetics and even promote and maintain oncogenic transformation. As a consequence, there has been intense scientific and clinical interest in targeting metabolic alterations that are commonly adopted by tumor cells for therapeutic purposes. In this review, we describe common metabolic alterations seen in tumor cells and discuss how these alterations are being investigated as potential targets for pharmacological intervention in preclinical and clinical settings. We also discuss some of the challenges associated with using tumor metabolism as a therapeutic target in cancer therapy, along with potential avenues to overcome these challenges.