NATURAL-KILLER (NK) CELLS IN CHRONIC PROGRESSIVE MULTIPLE-SCLEROSIS PATIENTS TREATED WITH LYMPHOBLASTOID INTERFERON
NATURAL-KILLER (NK) CELLS IN CHRONIC PROGRESSIVE MULTIPLE-SCLEROSIS PATIENTS TREATED WITH LYMPHOBLASTOID INTERFERON
复制标题
DOI：
10.1016/0165-5728(88)90109-9
复制
发表时间：
1988-11-01
影响因子：
3.3
通讯作者：
PATY, DW
中科院分区：
文献类型：
--
作者：
KASTRUKOFF, LF;MORGAN, NG;PATY, DW
与正常对照相比，慢性进行性多发性硬化症 (MS) 中的自然杀伤 (NK) 细胞功能活性（通过 51Cr 标记的 K-562 细胞裂解定义）和数量（通过抗 Leu-11 表型定义）显着降低。当比较年龄和性别匹配的人群时，与对照组相比，MS 中的 NK 细胞功能活性再次显着降低，但与其他医学疾病 (OMD) 的对照组相比则没有显着降低。然而，当 NK 细胞功能活性结果与 NK 细胞表型相结合时，MS 组可以与 OMD 组区分开来。连续 6 个月每天给予类淋巴母细胞干扰素后，NK 细胞活性在 48 小时和 1 周时显着增加。到 1 个月时，活性下降至略高于安慰剂治疗值的水平。结果可能反映了干扰素对成熟 NK 细胞活性的增强以及对前 NK 细胞募集的不同影响。
Natural killer (NK) cell functional activity, as defined by the lysis of 51Cr-labelled K-562 cells, and number, defined phenotypically by anti-Leu-11, are significantly decreased in chronic progressive multiple sclerosis (MS) when compared to normal controls. When age- and sex-matched populations are compared, NK cell functional activity is again significantly reduced in MS compared to controls but not when compared to a control group of other medical disease (OMD). The MS group could be differentiated from the OMD group, however, when results of NK cell functional activity are combined with NK cell phenotype. With the administration of lymphoblastoid interferon daily for 6 months, NK cell activity increased significantly at 48 h and 1 week. By 1 month, activity decreased to a level slightly above placebo treatment values. The results likely reflect interferon''s enhancement of mature NK cell activity combined with a variable effect on recruitment of pre-NK cells.