A LONGITUDINAL EEG STUDY OF MILD SENILE DEMENTIA OF ALZHEIMER TYPE - CHANGES AT 1 YEAR AND AT 2.5 YEARS
A LONGITUDINAL EEG STUDY OF MILD SENILE DEMENTIA OF ALZHEIMER TYPE - CHANGES AT 1 YEAR AND AT 2.5 YEARS
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DOI：
10.1016/0013-4694(85)91048-x
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发表时间：
1985-01-01
期刊：
影响因子：
--
通讯作者：
STORANDT, M
中科院分区：
文献类型：
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作者：
COBEN, LA;DANZIGER, W;STORANDT, M
这项静息脑电图纵向研究比较了阿尔茨海默型老年痴呆症 (SDAT) 患者和健康对照者，在 2.5 年的时间内进行了 3 次测试。测量值包括平均脑电图频率以及从功率谱分析获得的 α、β、θ 和 δ 频段的功率百分比。对左半球和右半球从枕骨到顶点的导数值进行平均。在健康老年人中，在研究期间，δ 值增加，β 值和平均频率均下降； θ 或 alpha 没有显着变化。在 SDAT 组中，所有 5 项脑电图测量值均发生显着变化； δ 和 θ 增加，β、α 和平均频率减少。 Theta 百分比功率可区分痴呆症的所有 4 个阶段（对照、轻度、中度和重度）。其他脑电图测量仅在某些阶段存在歧视。在SDAT theta、beta和平均频率的轻度阶段，已经与对照值不同。在中期阶段，这些差异仍然存在，阿尔法变得不同。 Delta 是最后发生变化的，在目前患有严重 SDAT 的小样本中，差异尚未达到显着性。
This longitudinal study of resting EEGs compared patients with senile dementia of Alzheimer type (SDAT) and healthy controls at 3 times of testing over a 2.5 year period. Measures included the mean EEG frequency as well as the precentage of power in alpha, beta, theta, and delta frequency bands obtained from power spectral analysis. The values from occipital to vertex derivations were averaged for the left and right hemispheres. In healthy older adults delta increased, and both beta and mean frequency decreased over the study period; there was no significant change in theta or alpha. In the SDAT group, all 5 EEG measures changed significantly; there were increases in delta and theta, and decreases in beta, alpha and mean frequency. Theta percentage power distinguished between all 4 stages of dementia (control, mild, moderate and severe). Other EEG measures discriminated only at certain stages. In the mild stage of SDAT theta, beta and mean frequency were already different from control values. In the moderate stage, these differences persisted, and alpha became different. Delta was the last to change, and in the present small sample of those with severe SDAT the difference had not yet reached significance.