Effects of cocaine on dopamine in subregions of the rat prefrontal cortex and their efferents to subterritories of the nucleus accumbens
Effects of cocaine on dopamine in subregions of the rat prefrontal cortex and their efferents to subterritories of the nucleus accumbens
复制标题
DOI：
10.1016/s0014-2999(99)00218-6
复制
发表时间：
1999-05-14
影响因子：
5
通讯作者：
Heidbreder, CA
中科院分区：
文献类型：
--
作者：
Hedou, G;Feldon, J;Heidbreder, CA
本研究旨在研究腹侧边缘前/边缘下皮层和背侧边缘前/前扣带皮层以及背侧边缘核的壳亚区对可卡因（20 mg/kg i. p.）运动活动和同时透析液多巴胺水平使用双探针微透析设计。基础多巴胺水平显着较高的腹内侧前额叶皮层相比，背内侧前额叶皮层和更高浓度的多巴胺也观察到在核心的脑桥核相比，其壳对应。皮质醇产生了显着的腹侧和背侧内侧前额叶皮质的多巴胺水平下降。与此相反，可卡因显着增加透析液多巴胺在壳的核多巴胺，而只有轻微的增加多巴胺观察到的核亚区。腹侧和背侧内侧前额叶皮质的多巴胺水平和透析液多巴胺浓度之间的显着的负相关关系，在壳和核心的丘脑核。最后，在腹侧和背侧内侧前额叶皮质，可卡因的运动反应的幅度呈负相关的透析液多巴胺水平。与此相反，可卡因的运动反应的幅度变得越来越大的多巴胺水平增加的壳的核。这些结果表明，在内侧前额叶皮层和脑桥核的分区多巴胺释放的模式在响应于可卡因的急性全身给药的解离。(C)1999 Elsevier Science B. V.保留所有权利。
The present study sought to investigate the contributions of the ventral prelimbic/infralimbic cortices and shell subterritory of the nucleus accumbens as well as the dorsal prelimbic/anterior cingulate cortices and core subregion of the nucleus accumbens to the acute systemic effects of cocaine (20 mg/kg i.p.) on both locomotor activity and simultaneous dialysate dopamine levels using a dual-probe microdialysis design. Basal dopamine levels were significantly higher in the ventral medial prefrontal cortex compared with the dorsal medial prefrontal cortex and higher concentrations of dopamine were also observed in the core of the nucleus accumbens compared with its shell counterpart. Cocaine produced a significant decrease in dopamine levels in both the ventral and dorsal medial prefrontal cortices. In contrast, cocaine significantly increased dialysate dopamine in the shell of the nucleus accumbens, whereas only a slight increase in dopamine was observed in the core subregion of the nucleus accumbens. A significant negative relationship between dopamine levels in the ventral and dorsal medial prefrontal cortices and dialysate dopamine concentrations in the shell and core of the nucleus accumbens was observed. Finally, in both the ventral and dorsal medial prefrontal cortices, the magnitude of the locomotor response to cocaine was inversely related to dialysate dopamine levels. In contrast, the magnitude of the locomotor response to cocaine became progressively larger as dopamine levels increased in the shell of the nucleus accumbens. These results show a dissociation in the pattern of dopamine release in subterritories of both the medial prefrontal cortex and nucleus accumbens in response to the acute systemic administration of cocaine. (C) 1999 Elsevier Science B.V. All rights reserved.