Two types of somatic recombination are necessary for the generation of complete immunoglobulin heavy-chain genes
Two types of somatic recombination are necessary for the generation of complete immunoglobulin heavy-chain genes
复制标题
两种类型的体细胞重组对于产生完整的免疫球蛋白重链基因是必需的
作者：
H. Sakano;R. Maki;Y. Kurosawa;W. Roeder;S. Tonegawa
至少两种类型的体细胞重组是从生殖系γ序列中产生完整的免疫球蛋白DNA2b基因所必需的。第一种类型的重组由三个独立的DNA片段组成，每个片段编码可变区的不同部分。第二种类型的重组将编码μ链恒定区的外显子替换为编码-γ2b链的相同区域的外显子。DNA测序研究表明，这两种类型的重组以不同的机制运作。
At least two types of somatic recombination are necessary for the generation of a complete immunoglobulin γ2b gene from germ-line DNA sequences. The first type of recombination consists of the assembly of three separate DNA segments, each encoding a different part of the variable region. The second type of recombination replaces the exons coding for the constant region of the μ chain with those coding for the same region of the -γ2b chain. The DNA sequencing studies suggest that the two types of recombination operate by different mechanisms.