Magnetic resonance perfusion-weighted imaging of acute cerebral infarction - Effect of the calculation methods and underlying vasculopathy
Magnetic resonance perfusion-weighted imaging of acute cerebral infarction - Effect of the calculation methods and underlying vasculopathy
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DOI：
10.1161/hs0102.101893
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发表时间：
2002-01-01
期刊：
影响因子：
8.3
通讯作者：
Yagi, K
中科院分区：
文献类型：
--
作者：
Yamada, K;Wu, O;Yagi, K
背景和目的-各种计算方法可用于估计MR灌注加权成像（PWI）的渡越时间。每种方法都可能影响PWI的结果。载瘤血管的狭窄闭塞性疾病是另一个可能影响PWI结果的因素。本研究的目的是阐明PWI. Methods的计算方法和潜在的血管病变的效果，从113例患者谁经历了PWI在研究期间，共12例非腔隙性缺血性中风谁被扫描后24小时内症状发作被选中的研究。患者人群包括6例颅外颈内动脉狭窄（>70%）的患者和6例无狭窄的个体。评价了七种不同的后处理方法：第一矩、峰面积比、达峰时间（TTP）、相对TTP、到达时间、半峰全宽和反卷积方法。随后的MR或CT图像被用来确定演变成梗死的区域，这是金标准。结果敏感性高的计算方法是第一时刻（敏感性，74%），TTP（敏感性，77%），和去卷积方法（敏感性，81%至94%）。在有和无颈内动脉狭窄的两组之间，颈内动脉狭窄组的大多数技术的特异性较低。即使在狭窄group. Conclusions的计算技术和存在的基础，血管病变PWI的结果有直接的影响，第一时刻和反卷积方法保持相对较高的特异性。即使在存在狭窄闭塞性疾病的情况下也具有高灵敏度的方法是具有来自梗死周围动脉的动脉输入函数的一阶矩和去卷积方法;去卷积方法是上级选择，因为病变的显著性更高。
Background and Purpose-Various calculation methods are available to estimate the transit-time on MR perfusion-weighted imaging (PWI). Each method may affect the results of PWI. Steno-occlusive disease in the parent vessels is another factor that may affect the results of the PWI. The purpose of this study was to elucidate the effect of the calculation methods and underlying vasculopathy on PWI.Methods-From a pool of 113 patients who had undergone PWI during the study period, a total of 12 patients with nonlacunar ischemic strokes who were scanned within 24 hours after onset of symptom were selected for the study. The patient population consisted of 6 patients who had extracranial internal carotid artery stenosis (>70%) and 6 individuals without stenosis. Seven different postprocessing methods were evaluated: first moment, ratio of area to peak, time to peak (TTP), relative TTP, arrival time, full-width at half-maximum, and deconvolution methods. Follow-up MR or CT images were used to determine the areas that evolved into infarcts, which served as the gold standard. Sensitivity and specificity of each transit time technique were calculated.Results-Calculation methods with high sensitivity were the first moment (sensitivity, 74%), TTP (sensitivity, 77%), and deconvolution methods (sensitivity, 81% to 94%). Between the 2 groups with and without internal carotid artery stenosis, the specificity of most of the techniques was lower in the internal carotid artery stenosis group. The first moment and deconvolution methods maintained relatively high specificity even in the stenosis group.Conclusions-The calculation technique and presence of underlying, vasculopathy have a direct impact on the results of PWI. The methods with high sensitivity even in the presence of steno-occlusive disease were the first moment and deconvolution methods with arterial input function derived from the peri-infarct arteries; the deconvolution method was the superior choice because of higher lesion conspicuity.