A clinicopathological and molecular analysis of 200 traditional serrated adenomas
A clinicopathological and molecular analysis of 200 traditional serrated adenomas
复制标题
DOI：
10.1038/modpathol.2014.122
复制
发表时间：
2015-03-01
期刊：
影响因子：
7.5
通讯作者：
Whitehall, Vicki L. J.
中科院分区：
文献类型：
--
作者：
Bettington, Mark L.;Walker, Neal I.;Whitehall, Vicki L. J.
传统的锯齿状腺瘤是最不常见的结直肠锯齿状息肉。这些息肉的临床病理特征和分子驱动因素需要进一步研究。我们前瞻性地收集了200例普通和晚期传统锯齿状腺瘤，并对所有病例进行了BRAF和KRAS突变分析、CpG岛甲基化表型分析和7种抗体（MLH 1、β-连环蛋白、p53、p16、Ki 67、CK 7和CK 20）的免疫组化。患者的平均年龄为64岁，50%为女性。71%的息肉位于远端。19%的病例存在晚期组织学（明显的异型增生或癌）。BRAF突变占67%，KRAS突变占22%。BRAF突变的传统锯齿状腺瘤更常见于近端（39%对2%; P
The traditional serrated adenoma is the least common colorectal serrated polyp. The clinicopathological features and molecular drivers of these polyps require further investigation. We have prospectively collected a cohort of 200 ordinary and advanced traditional serrated adenomas and performed BRAF and KRAS mutational profiling, CpG island methylator phenotype analysis, and immunohistochemistry for a panel of 7 antibodies (MLH1, beta-catenin, p53, p16, Ki67, CK7, and CK20) on all cases. The mean age of the patients was 64 years and 50% were female. Of the polyps, 71% were distal. Advanced histology (overt dysplasia or carcinoma) was present in 19% of cases. BRAF mutation was present in 67% and KRAS mutation in 22%. BRAF mutant traditional serrated adenomas were more frequently proximal (39% versus 2%; P