Modification of the projection from the sensory cortex to the motor cortex following the elimination of thalamic projections to the motor cortex in cats.
Modification of the projection from the sensory cortex to the motor cortex following the elimination of thalamic projections to the motor cortex in cats.
复制标题
在消除猫的丘脑对运动皮层的投射后，从感觉皮层到运动皮层的投射发生改变。
DOI：
10.1016/0006-8993(85)90838-8
复制
发表时间：
1985
期刊：
影响因子：
2.9
通讯作者：
Robinson,H
中科院分区：
文献类型：
--
作者：
Asanuma,H;Kosar,E;Tsukahara,N;Robinson,H
检查从感觉皮层2区到运动皮层的投射，发现丘脑腹外侧核损伤后发生了实质性变化。这些观察到的变化如下。(1)刺激2区诱发电位的极性在运动皮层的深度发生逆转，而在正常动物中，没有逆转。(2)损毁VL后，2区诱发的运动皮层神经元EPSP的幅值增大。(3)所观察到的EPSP的形状的特征在于多个峰，而在正常动物中，EPSP通常是光滑的和单相的。(4)从2区接收短潜伏期输入的神经元分布在整个运动皮层的深处，而在正常动物中，它们仅位于上层（第二层和第三层）。(5)细胞内注射HRP显示，接受短潜伏期输入的神经元不仅限于典型的星状细胞，而且还包括具有细长胞体和极化分支的双极或双簇状神经元。这些神经元位于浅层（II和III）以及深层（V）。(6)它的结论是，丘脑输入的消除导致皮质输入到运动皮层的加强。随后观察到的皮质投射延伸到最初不受联合纤维支配的神经元。(7)结果提示，丘脑损伤后的功能恢复部分是由于感觉皮质向运动皮质投射的重组。
Examination of the projection from area 2 of the sensory cortex to the motor cortex revealed substantial changes following lesion of the ventrolateral nucleus of the thalamus. These observed changes were as follows. (1) The polarity of the evoked potentials elicited by area 2 stimulation reversed in the depth of the motor cortex whereas in normal animals, there was no reversal. (2) The amplitude of area 2-elicited EPSPs in the motor cortical neurons became greater following the lesion of VL. (3) The shape of the observed EPSPs was characterized by multiple peaks whereas in normal animals, the EPSPs were generally smooth and monophasic. (4) Neurons receiving a short-latency input from area 2 were distributed throughout the depths of the motor cortex whereas in normal animals, they were located only in the upper layers (layers II and III). (5) Intracellular injection of HRP revealed that the neurons receiving short-latency input were not restricted to typical stellate type cells, but also included bipolar or bitufted neurons with elongated cell bodies and polarized arborizations. These neurons were located in the superficial (II and III) as well as the deep (V) layer. (6) It is concluded that the elimination of thalamic input resulted in the reinforcement of the corticocortical input to the motor cortex. The subsequently observed corticocortical projection extended to neurons not originally innervated by the association fibers. (7) The results suggested that functional recovery following thalamic lesion is partly due to reorganization of projections from the sensory cortex to the motor cortex.