Costless metabolic secretions as drivers of interspecies interactions in microbial ecosystems
Costless metabolic secretions as drivers of interspecies interactions in microbial ecosystems
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DOI：
10.1038/s41467-018-07946-9
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发表时间：
2019-01-09
影响因子：
16.6
通讯作者：
Segre, Daniel
中科院分区：
文献类型：
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作者：
Pacheco, Alan R.;Moel, Mauricio;Segre, Daniel
代谢交换调节微生物之间的相互作用，有助于解释微生物群落的多样性。由于这些互动往往涉及健身成本，目前尚不清楚如何才能实现稳定的合作。在这里，我们使用基因组规模的代谢模型来调查“无成本”代谢物(即那些不会对生产者造成健康成本的代谢物)的释放是否可以成为微生物间相互作用的显著驱动因素。通过在组合环境中对24个物种进行200多万个成对生长模拟，我们确定了大量可以免费分泌的代谢物，从而产生了充足的交叉喂养机会。除了提供推测相互作用的图谱外，我们还表明，缺氧条件可以通过提供更多交换廉价代谢物的机会来促进互惠作用，从而导致稳定的生态网络基序的过度代表。这些结果可能有助于确定自然群落中的相互作用模式，并为合成微生物联合体的设计提供信息。
Metabolic exchange mediates interactions among microbes, helping explain diversity in microbial communities. As these interactions often involve a fitness cost, it is unclear how stable cooperation can emerge. Here we use genome-scale metabolic models to investigate whether the release of "costless" metabolites (i.e. those that cause no fitness cost to the producer), can be a prominent driver of intermicrobial interactions. By performing over 2 million pairwise growth simulations of 24 species in a combinatorial assortment of environments, we identify a large space of metabolites that can be secreted without cost, thus generating ample cross-feeding opportunities. In addition to providing an atlas of putative interactions, we show that anoxic conditions can promote mutualisms by providing more opportunities for exchange of costless metabolites, resulting in an overrepresentation of stable ecological network motifs. These results may help identify interaction patterns in natural communities and inform the design of synthetic microbial consortia.