Control of homeostatic proliferation by regulatory T cells
Control of homeostatic proliferation by regulatory T cells
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DOI：
10.1172/jci25463
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发表时间：
2005-12-01
影响因子：
15.9
通讯作者：
Lafaille, JJ
中科院分区：
文献类型：
--
作者：
Shen, SQ;Ding, Y;Lafaille, JJ
T 细胞的稳态增殖导致效应/记忆细胞的产生，这有可能对宿主造成伤害。 Tregs 在控制稳态增殖中的作用尚不清楚。在这项研究中，我们利用含有或缺乏 Tregs 的小鼠作为单克隆或多克隆 T 细胞的受体。我们观察到，虽然 Tregs 完全阻止了对自身配体表现出低亲和力的 T 细胞的细胞分裂，但它们对表现出较高亲和力的 T 细胞进入细胞周期的影响虽然显着，但不太明显。 Tregs 的存在导致 T 细胞积累减少，细胞凋亡增强，并损害向细胞因子产生状态的分化。我们得出结论，Tregs 在控制稳态增殖中发挥着重要作用。
Homeostatic proliferation of T cells leads to the generation of effector/memory cells, which have the potential to cause harm to the host. The role of Tregs in the control of homeostatic proliferation is unclear. In this study we utilized mice that either harbor or lack Tregs as recipients of monoclonal or polyclonal T cells. We observed that while Tregs completely prevented cell division of T cells displaying low affinity for self ligands, they had a less marked, albeit significant, effect on cell cycle entry of T cells displaying higher affinity. The presence of Tregs resulted in a lower accumulation of T cells, enhanced apoptosis, and impaired differentiation to a cytokine-producing state. We conclude that Tregs play a major role in the control of homeostatic proliferation.