Role of Gender in Morbidity and Mortality of Extremely Premature Neonates
Role of Gender in Morbidity and Mortality of Extremely Premature Neonates
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DOI：
10.1055/s-0031-1284225
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发表时间：
2012-03-01
影响因子：
2
通讯作者：
Piedboeuf, Bruno
中科院分区：
文献类型：
--
作者：
Binet, Marie-Eve;Bujold, Emmanuel;Piedboeuf, Bruno
我们调查了性别对极早产儿（= 3、视网膜病变等级>= 3、通气天数和住院时间）生存和短期结局的影响。在2744例极早产儿中，1480例（54%）为男性，1264例（46%）为女性。女性新生儿的平均出生体重在每一周胎龄显著降低。虽然在出院时的存活率方面没有发现性别之间的显著差异，但BPD的患病率、合并不良结局和24 - 26周出生的婴儿的死亡率在男性中显著较高。这项研究表明，在后表面活性剂时代，男性仍然处于呼吸系统并发症的较高风险，并且在妊娠24至26周之间出生时可能具有较高的死亡率。
We investigated the effect of gender on survival and short-term outcomes of extremely premature infants (= 3, retinopathy grade >= 3, days on ventilation, and length of hospital stay. Among 2744 extremely premature infants, 1480 (54%) were male and 1264 (46%) were female. Mean birth weight of female neonates was significantly lower at each week of gestational age. Although no significant difference in survival at discharge was found between genders overall, the prevalence of BPD, combined adverse outcomes, and mortality for infants born between 24 and 26 weeks were significantly higher in males. This study suggests that, in the postsurfactant era, males remain at higher risk of respiratory complications and may have higher mortality when born between 24 and 26 weeks of gestation.