Targeted Treatment for Bacterial Infections: Prospects for Pathogen-Specific Antibiotics Coupled with Rapid Diagnostics.
Targeted Treatment for Bacterial Infections: Prospects for Pathogen-Specific Antibiotics Coupled with Rapid Diagnostics.
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DOI：
10.1016/j.tet.2015.09.069
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发表时间：
2016-06-23
期刊：
影响因子：
2.1
通讯作者：
Mitchell DA
中科院分区：
文献类型：
--
作者：
Maxson T;Mitchell DA
抗生素是现代医学的基石，大大减轻了传染病的负担。然而，常用的广谱抗生素可能对人体微生物组造成重大的附带损害，导致从过敏性结肠炎到耐药性快速传播的并发症。采用针对特定病原体的窄谱抗生素可以缓解这种困境，并提供额外的工具来扩大受到不可避免的耐药性威胁的抗生素库。为了有效地利用病原体特异性抗生素，需要改进临床诊断，新的分子诊断学正准备满足这一需求。在这里，我们回顾了最近的趋势和未来的前景，部署较窄的频谱抗生素加上快速诊断。此外，我们讨论了这种新兴的方法来控制细菌感染性疾病的理论优势和局限性。
Antibiotics are a cornerstone of modern medicine and have significantly reduced the burden of infectious diseases. However, commonly used broad-spectrum antibiotics can cause major collateral damage to the human microbiome, causing complications ranging from antibiotic-associated colitis to the rapid spread of resistance. Employing narrower spectrum antibiotics targeting specific pathogens may alleviate this predicament as well as provide additional tools to expand an antibiotic repertoire threatened by the inevitability of resistance. Improvements in clinical diagnosis will be required to effectively utilize pathogen-specific antibiotics and new molecular diagnostics are poised to fulfill this need. Here we review recent trends and the future prospects of deploying narrower spectrum antibiotics coupled with rapid diagnostics. Further, we discuss the theoretical advantages and limitations of this emerging approach to controlling bacterial infectious diseases.