A portable near infrared spectroscopy system for bedside monitoring of newborn brain
A portable near infrared spectroscopy system for bedside monitoring of newborn brain
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DOI：
10.1186/1475-925x-4-29
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发表时间：
2005-01-01
影响因子：
3.9
通讯作者：
Onaral, Banu
中科院分区：
文献类型：
--
作者：
Bozkurt, Alper;Rosen, Arye;Onaral, Banu
背景：新生儿重症监护室（NICU）对危重新生儿进行监测。在NICU，他们面临的最重要的问题之一是脑损伤的风险。需要持续监测新生儿的脑功能，以防止任何潜在的脑损伤。这种类型的监测不应干扰新生儿的重症监护。因此，它应该是非侵入性和portable.Methods：在本文中，一个低成本，电池供电，双波长，连续波近红外光谱系统连续床旁血流动力学监测新生儿脑。该系统已被设计成通过优化波长复用参数来优化SNR，特别强调与烧伤有关的安全问题。SNR的改善，利用整个动态范围已被满意的修改在模拟circuits.Results和结论：作为一个结果，拍摄限制的SNR为67 dB，已达到10 Hz的时间分辨率。当使用现成的1850 mAh-7.2 V电池时，系统可以运行30小时以上而无需充电。实验室测试与光学幻影和初步的数据记录在新生儿重症监护室证明了该系统作为一个可靠的临床工具，在床边区域监测新生儿脑代谢重症监护下的潜力。
Background: Newborns with critical health conditions are monitored in neonatal intensive care units (NICU). In NICU, one of the most important problems that they face is the risk of brain injury. There is a need for continuous monitoring of newborn's brain function to prevent any potential brain injury. This type of monitoring should not interfere with intensive care of the newborn. Therefore, it should be non-invasive and portable.Methods: In this paper, a low-cost, battery operated, dual wavelength, continuous wave near infrared spectroscopy system for continuous bedside hemodynamic monitoring of neonatal brain is presented. The system has been designed to optimize SNR by optimizing the wavelength-multiplexing parameters with special emphasis on safety issues concerning burn injuries. SNR improvement by utilizing the entire dynamic range has been satisfied with modifications in analog circuitry.Results and Conclusion: As a result, a shot-limited SNR of 67 dB has been achieved for 10 Hz temporal resolution. The system can operate more than 30 hours without recharging when an off-the-shelf 1850 mAh-7.2 V battery is used. Laboratory tests with optical phantoms and preliminary data recorded in NICU demonstrate the potential of the system as a reliable clinical tool to be employed in the bedside regional monitoring of newborn brain metabolism under intensive care.