Association of Cholesterol Levels with Mortality and Cardiovascular Events among Patients with CKD and Different Amounts of Proteinuria
Association of Cholesterol Levels with Mortality and Cardiovascular Events among Patients with CKD and Different Amounts of Proteinuria
复制标题
DOI：
10.2215/cjn.02350213
复制
发表时间：
2013-11-07
影响因子：
9.8
通讯作者：
Chen, Hung-Chun
中科院分区：
文献类型：
--
作者：
Chen, Szu-Chia;Hung, Chi-Chih;Chen, Hung-Chun
背景与目的营养不良和/或炎症可能改变CKD患者总胆固醇与心血管疾病的风险关系。然而，目前尚不清楚总胆固醇与心血管事件和死亡率的关系是否因蛋白尿而异。设计、环境、参与者和测量本研究在2002年11月至2009年5月期间从一家医疗中心和一家地区医院招募了3303名CKD 3-5期患者，随访至2010年7月。结果在中位2.8年的随访期间，有471例（14.3%）死亡，545例（16.5%）心血管事件。在调整后的Cox模型中，总胆固醇的两个最高四分位数（风险比为1.90,95%可信区间为1.16至3.13，风险比为2.00,95%可信区间为1.18至3.39，分别为1）与尿蛋白与肌酐比值较高的患者全因死亡风险相关
Background and objectivesMalnutrition and/or inflammation may modify the risk relationship of total cholesterol with cardiovascular disease in CKD patients. However, it is unclear whether the relationship of total cholesterol with cardiovascular events and mortality varies by proteinuria.Design, setting, participants, & measurementsThis study enrolled 3303 patients with CKD stages 3-5 from a medical center and a regional hospital between November of 2002 and May of 2009 and followed the patients until July of 2010.ResultsDuring a median 2.8-year follow-up, there were 471 (14.3%) deaths and 545 (16.5%) cardiovascular events. In an adjusted Cox model, the two highest quartiles of total cholesterol (hazard ratio, 1.90; 95% confidence interval, 1.16 to 3.13 and hazard ratio, 2.00; 95% confidence interval, 1.18 to 3.39 versus quartile 1, respectively) were associated with a significant higher risk of all-cause mortality in patients with urine protein-to-creatinine ratio