Wideband Fully-Programmable Dual-Mode CMOS Analogue Front-End for Electrical Impedance Spectroscopy
Wideband Fully-Programmable Dual-Mode CMOS Analogue Front-End for Electrical Impedance Spectroscopy
复制标题
用于电阻抗光谱的宽带完全可编程双模 CMOS 模拟前端
DOI：
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发表时间：
2016
期刊：
影响因子：
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通讯作者：
A. Demosthenous
中科院分区：
文献类型：
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作者：
V. Valente;A. Demosthenous
本文提出了一种用于电化学和生物阻抗分析的多通道双模CMOS模拟前端（AFE）。电流模式和电压模式读数集成在同一芯片上，可以提供一个适应性强的平台，将单细胞生物传感器研究与大规模组织或器官分析相关联，用于实时癌症检测、成像和表征。该芯片采用180纳米CMOS技术，结合了两个电流读出（CR）通道和四个电压读出（VR）通道，适用于双极和四极电阻抗谱（EIS）分析。每个VR通道的面积为0.48 mm 2，工作带宽为8mhz，线性增益在−6 dB到42 dB之间。CR通道的增益可设置为10 kΩ、50 kΩ或100 kΩ，动态范围为80 db，对输入电流在10 nA至100 μ a之间具有非常好的线性响应。该芯片每个通道的功耗在530 μ A到690 μ A之间，工作在1.8 v电源下。该芯片用于测量电容式交叉指电极在盐水溶液中的阻抗。测量结果显示与使用商用阻抗分析仪获得的结果密切匹配。该芯片将成为一个完全灵活和可配置的全集成双模EIS系统的一部分，用于阻抗传感器和生物阻抗分析。
This paper presents a multi-channel dual-mode CMOS analogue front-end (AFE) for electrochemical and bioimpedance analysis. Current-mode and voltage-mode readouts, integrated on the same chip, can provide an adaptable platform to correlate single-cell biosensor studies with large-scale tissue or organ analysis for real-time cancer detection, imaging and characterization. The chip, implemented in a 180-nm CMOS technology, combines two current-readout (CR) channels and four voltage-readout (VR) channels suitable for both bipolar and tetrapolar electrical impedance spectroscopy (EIS) analysis. Each VR channel occupies an area of 0.48 mm 2 , is capable of an operational bandwidth of 8 MHz and a linear gain in the range between −6 dB and 42 dB. The gain of the CR channel can be set to 10 kΩ, 50 kΩ or 100 kΩ and is capable of 80-dB dynamic range, with a very linear response for input currents between 10 nA and 100 μ A. Each CR channel occupies an area of 0.21 mm 2 . The chip consumes between 530 μ A and 690 μ A per channel and operates from a 1.8-V supply. The chip was used to measure the impedance of capacitive interdigitated electrodes in saline solution. Measurements show close matching with results obtained using a commercial impedance analyser. The chip will be part of a fully flexible and configurable fully-integrated dual-mode EIS system for impedance sensors and bioimpedance analysis.