Myo-inositol turnover in the intact rat brain: increased production after d-amphetamine.
Myo-inositol turnover in the intact rat brain: increased production after d-amphetamine.
复制标题
完整大鼠大脑中的肌醇周转：d-苯丙胺后产量增加。
DOI：
10.1111/j.1471-4159.1981.tb00590.x
复制
发表时间：
1981
影响因子：
4.7
通讯作者：
Barkai,AI
中科院分区：
文献类型：
--
作者：
Barkai,AI
在体内，根据脑室室中内源性肌醇的出现率，估计氨基甲酸乙酯麻醉大鼠脑中肌醇的表观周转率。采用心室池灌注技术结合同位素稀释[14 C]肌醇来确定脑产生的肌醇及其被D-苯丙胺修饰的出现率。脑室系统中出现率的平均值为0.75 nmol/min。在给予d-苯丙胺后，观察到该比率呈剂量依赖性增加。还研究了从灌流液中内源性去除肌醇，发现部分由不受d-苯丙胺影响的饱和转运系统介导。肌醇从血液进入脑室系统的速率非常低，仅占总出现率的2%，表明大鼠脑室液中的大部分肌醇来源于大脑。
Apparent turnover ofmyo‐inositol in the brain of urethane‐anesthetized rats was estimatedin vivofrom the rate of appearance of endogenousmyo‐inositol in the cerebroventricular compartment. Ventricular‐cisternal perfusion technique combined with isotope dilution of [14C]myo‐inositol was used to determine the rate of appearance of brain‐producedmyo‐inositol and its modification byd‐amphetamine. A mean value of 0.75 nmol/min was obtained for the rate of appearance in the cerebroventricular system. A dose dependent increase in this rate was seen after the administration ofd‐ampheta‐mine. The endogenous removal ofmyo‐inositol from the perfusate was also studied and found to be mediated in part by a saturable transport system that was not influenced by d‐amphetamine. The rate of entry ofmyo‐inositol from blood to the erebroventricular system was very low and accounted for only 2% of the total rate of appearance, indicating that the majority ofmyo‐inositol in the rat cerebroventricular fluid originates in the brain.