Auditory Memory Decrements, Without Dissimulation, among Patients with Major Depressive Disorder
Auditory Memory Decrements, Without Dissimulation, among Patients with Major Depressive Disorder
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DOI：
10.1093/arclin/acr041
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发表时间：
2011-08-01
影响因子：
2.6
通讯作者：
Langenecker, Scott A.
中科院分区：
文献类型：
--
作者：
Considine, Ciaran M.;Weisenbach, Sara L.;Langenecker, Scott A.
有人提出了这样一个问题，即重度抑郁症（MDD）患者在记忆任务中的表现不佳是否可能是由于支持记忆功能的神经回路的不佳或可变努力或疾病相关中断的结果。本研究检查了45例MDD患者（M年龄= 47.82，SD = 19.55）相对于32名健康对照（HC; M年龄= 51.03，SD = 22.09）的任务参与和听觉记忆任务的测量性能。100%的HC和MDD志愿者在正式的任务参与度测量中表现出足够的努力。在听觉学习和记忆测试中，MDD受试者的表现明显比HC受试者差。目前的研究结果表明，听觉记忆困难确实发生在那些与抑郁症，在这一组的性能下降可能与其他因素缺乏努力。
Questions have been raised about whether poor performance on memory tasks by individuals with major depressive disorder (MDD) might be the result of poor or variable effort or disease-related disruption of neural circuits supporting memory functions. The present study examined performance on a measure of task engagement and on an auditory memory task among 45 patients with MDD (M age = 47.82, SD = = 19.55) relative to 32 healthy controls (HC; M age = 51.03, SD = 22.09). One-hundred percent of HC and MDD volunteers performed above the threshold for adequate effort on a formal measure of task engagement. The MDD subjects performed significantly more poorly than the HC subjects on an auditory learning and memory test. The present results suggest that auditory memory difficulties do occur among those with MDD and that decrements in performance in this group may be related to factors other than lack of effort.