PHOTOSENSITIZING MEROCYANINE DYES BASED ON SELENOBARBITURIC ACID
PHOTOSENSITIZING MEROCYANINE DYES BASED ON SELENOBARBITURIC ACID
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DOI：
10.1080/10426509208045864
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发表时间：
1992-01-01
影响因子：
1.3
通讯作者：
SIEBER, F
中科院分区：
文献类型：
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作者：
GUNTHER, WHH;SEARLE, R;SIEBER, F
合成了部花青 540 (MC540) 的结构类似物，以探索作用的生物学机制并增强病毒灭活作用。描述了已知的和修饰的部花青敏化剂的新型嘧啶-2-硒酮类似物。将硒置于巴比妥位点的一个令人惊讶的结果是单线态氧 (1O2) 的光生效率提高了约 100 倍。相反，直接连接到发色团 π 系统的硒的效果要差得多。更多1O2的产生体现在新型染料的生物功效大大提高。硫酮和硒酮染料都显示出含有萘并恶唑或萘并噻唑成分的分子之间令人费解的从高到低生物活性异构体效应。
Structural analogs of Merocyanine 540 (MC540) were synthesized to probe biological mechanisms of action and to enhance viral inactivation. Novel pyrimidine-2- selone analogs of known and modified merocyanine sensitizers are described. A surprising result of placing selenium at the barbiturate site was the ∼ 100-fold enhancement of photogeneration efficiency for singlet oxygen (1O2). Conversely, selenium directly attached to the chromophore π-system was much less efficacious. The production of more1O2is reflected in greatly improved biological effectiveness of the new dyes. A puzzling high to low bioactivity isomer effect among molecules containing naphthoxazole or naphthothiazole components is shown by both thione and selone dyes.