Monocyte homeostasis and the plasticity of inflammatory monocytes
Monocyte homeostasis and the plasticity of inflammatory monocytes
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DOI：
10.1016/j.cellimm.2014.05.010
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发表时间：
2014-09-01
影响因子：
4.3
通讯作者：
Weninger, Wolfgang
中科院分区：
文献类型：
--
作者：
Mitchell, Andrew J.;Roediger, Ben;Weninger, Wolfgang
单核细胞是在骨髓中发育并在血液中循环的单核髓样细胞。尽管它们长期以来一直被认为在组织巨噬细胞的再生中发挥作用，但最近的许多研究对这一观点提出了质疑，这迫使人们重新评估它们的生物学。这里我们讨论单核细胞的发育，以及血液中单核细胞亚群的稳态控制。我们还概述了单核细胞亚群的已知功能。最后，我们强调了单核细胞的可塑性，它们能够根据来自局部微环境的信号进行一系列显着的表型和功能变化。(C) 2014爱思唯尔公司版权所有。
Monocytes are mononuclear myeloid cells that develop in the bone marrow and circulate within the bloodstream. Although they have long been argued to play a role in the repopulation of tissue-resident macrophages, this has been questioned by numerous recent studies, which has forced a reappraisal of their biology. Here we discuss monocyte development, as well as the homeostatic control of monocyte subpopulations within the blood. We also outline the known functions of monocyte subsets. Finally, we highlight the plastic nature of monocytes, which are capable of a remarkable range of phenotypic and functional changes that depend on signals from local microenvironments. (C) 2014 Elsevier Inc. All rights reserved.