Necroptosis in acute kidney injury: a shedding light.
Necroptosis in acute kidney injury: a shedding light.
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急性肾损伤中的坏死性凋亡：一个启示
DOI：
10.1038/cddis.2016.37
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发表时间：
2016-03-03
影响因子：
9
通讯作者：
Yang C
中科院分区：
文献类型：
--
作者：
Wang S;Zhang C;Hu L;Yang C
急性肾损伤（阿基）是一种常见且严重的临床疾病，在世界各地都有沉重的健康负担。尽管有支持性治疗，但与阿基相关的死亡率仍然很高。我们对阿基过程中复杂的细胞死亡机制的了解有限，阻碍了理想治疗方法的开发。坏死性凋亡是近年来发现的一种新的细胞死亡形式，可导致神经系统疾病和组织损伤。越来越多的证据表明，坏死性凋亡在各种类型的阿基的发病机制中具有重要作用。因此，我们在这里提出的信号通路和坏死性凋亡的主要调节，是潜在的候选人的治疗策略。此外，我们强调的坏死性凋亡在阿基的潜在作用和相应的机制的基础上的最新进展，并讨论了可能的治疗方案的基础上操纵坏死性凋亡。总之，该领域的进展为临床实践中阿基的预防和管理提供了新的思路。
Acute kidney injury (AKI) is a common and severe clinical condition with a heavy healthy burden around the world. In spite of supportive therapies, the mortality associated with AKI remains high. Our limited understanding of the complex cell death mechanism in the process of AKI impedes the development of desirable therapeutics. Necroptosis is a recently identified novel form of cell death contributing to numerable diseases and tissue damages. Increasing evidence has suggested that necroptosis has an important role in the pathogenesis of various types of AKI. Therefore, we present here the signaling pathways and main regulators of necroptosis that are potential candidate for therapeutic strategies. Moreover, we emphasize on the potential role and corresponding mechanisms of necroptosis in AKI based on recent advances, and also discuss the possible therapeutic regimens based on manipulating necroptosis. Taken together, the progress in this field sheds new light into the prevention and management of AKI in clinical practice.