Acetate labeling patterns of dinoflagellate polyketides, amphidinols 2, 3 and 4
Acetate labeling patterns of dinoflagellate polyketides, amphidinols 2, 3 and 4
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DOI：
10.1016/s0040-4020(01)00481-1
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发表时间：
2001-06-25
期刊：
影响因子：
2.1
通讯作者：
Rhodes, LL
中科院分区：
文献类型：
--
作者：
Houdai, T;Matsuoka, S;Rhodes, LL
两性醇是一种聚酮化合物代谢物，主要包含具有多羟基的长直链和聚烯烃，由海洋甲藻 Amphidinium carterae 和 A. klebsii 产生。两性醇 2、3 和 4 的乙酸酯掺入实验表明，它们由五个规则的 Ct 延伸序列组成，这些序列由连续的乙酸酯-甲基衍生的碳分隔。这些发现支持了常规序列中的 Cl-缺失机制，这可以通过 Favorski 型反应或 Tiffeneau-Demjanov 重排来解释。 (C) 2001 Elsevier Science Ltd. 保留所有权利。
Amphidinols, which are polyketide metabolites chiefly comprising a long linear chain with polyhydroxyl groups and polyolefins, are produced by marine dinoflagellates Amphidinium carterae and A. klebsii. The acetate incorporation experiments of amphidinols 2, 3 and 4 revealed that they are built up with five regular Ct-elongation sequences, which are separated by continuous acetate-methyl derived carbons. The findings support the Cl-deletion mechanism from the regular sequence, which could be accounted for either by Favorski-type reaction or by Tiffeneau-Demjanov rearrengement. (C) 2001 Elsevier Science Ltd. All rights reserved.