Morbidity and mortality in antiphospholipid syndrome based on cluster analysis: a 10-year longitudinal cohort study
Morbidity and mortality in antiphospholipid syndrome based on cluster analysis: a 10-year longitudinal cohort study
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DOI：
10.1093/rheumatology/keaa542
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发表时间：
2021-03-01
期刊：
影响因子：
5.5
通讯作者：
Atsumi, Tatsuya
中科院分区：
文献类型：
--
作者：
Ogata, Yusuke;Fujieda, Yuichiro;Atsumi, Tatsuya
目标。采用聚类分析的方法，找出APS患者预后最差的亚组，明确其特点。这是一项针对APS患者的纵向回顾性队列研究。根据APL的临床资料和临床资料，进行聚类分析，将患者分为亚组。事件定义为血栓形成、严重出血和死亡。共有168名APS患者纳入研究。聚类分析将患者分为三个亚组：A组(n=61)：继发性APS；B组(n=56)：心血管危险和动脉血栓形成；C组(n=61)：APL和静脉血栓三重阳性。B组的事件发生率和病死率明显高于其他组(P=0.0112，P=0.0471，P<0.05)。通过聚类分析，明确预后最差的APS患者的特征。心血管疾病的危险因素可能会进一步增加APS患者的事件。
Objective. Using cluster analysis, to identify the subgroup of patients with APS with the poorest prognosis and clarify the characteristics of that subgroup.Methods. This is a longitudinal retrospective cohort study of APS patients. Using clinical data and the profile of aPL, cluster analysis was performed to classify the patients into subgroups. Events were defined as thrombosis, severe bleeding, and mortality.Results. A total of 168 patients with APS were included. Cluster analysis classified the patients into three subgroups; Cluster A (n = 61): secondary APS, Cluster B (n = 56): accumulation of cardiovascular risks and arterial thrombosis, Cluster C (n = 61): triple positivity of aPL and venous thrombosis. Cluster B showed significantly higher frequency of the events and higher mortality compared with the other clusters (P = 0.0112 for B vs A and P = 0.0471 for B vs C).Conclusion. Using cluster analysis, we clarified the characteristics of the APS patients with the poorest prognosis. Risk factors for cardiovascular disease may further increase events in patients with APS.