Distribution of perfluorochemicals between sera and milk from the same mothers and implications for prenatal and postnatal exposures
Distribution of perfluorochemicals between sera and milk from the same mothers and implications for prenatal and postnatal exposures
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DOI：
10.1016/j.envpol.2010.09.008
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发表时间：
2011-01-01
影响因子：
8.9
通讯作者：
Lee, Jong-Hyeon
中科院分区：
文献类型：
--
作者：
Kim, Seung-Kyu;Lee, Kyu Tae;Lee, Jong-Hyeon
在母体血清、脐带血清和母乳的配对样本中测量了六种全氟羧酸盐 (PFCA)、四种全氟烷基磺酸盐 (PFAS) 和一种磺酰胺的水平。对于所有测量的化合物，母体血清和脐带血清彼此强烈相关（r > 0.5 且 p < 0.01）。然而，两种血清基质之间的化合物组成特征存在显着差异，脐带血清中长链化合物的消耗更多。 PFCA 组内每增加一个单位的 -CF2 链，从母体到脐带血清 (TFCS/MS) 的转移效率值就会降低 70%，而全氟辛烷磺酸 (PFOS) 则比全氟辛酸 (PFOA) 降低一半。与两种血清基质之间浓度的强相关性相反，母乳中的化合物模式与血清中的化合物模式有很大不同。因此，在评估产前和产后暴露时，必须考虑化合物和基质特异性转移。 (C) 2010 Elsevier Ltd. 保留所有权利。
The levels of six perfluorocarboxylates (PFCAs), four perfloroallcylsulfonates (PFASs), and one sulfonamide were measured in paired samples of maternal serum, umbilical cord serum, and breast milk. The maternal and cord sera were strongly correlated with each other for all measured compounds (r > 0.5 and p < 0.01). Nevertheless, there was a significant difference in compound composition profile between the two sera matrices, with a more depletion of the longer chain compounds in cord serum. The transfer efficiency values from maternal to cord serum (TFCS/MS) decreased by 70% with each increasing unit of -CF2 chain within a PFCA group, and for perfluorooctanesulfonate (PFOS), by a half compared to perfluorooctanoate (PFOA). In contrast to the strong correlation in concentrations between the two sera matrices, the pattern of compounds in breast milk differed considerably with those in sera. Accordingly, compound- and matrix-specific transfer must be considered when assessing prenatal and postnatal exposure. (C) 2010 Elsevier Ltd. All rights reserved.