Clinical Application and Educational Training for Pharmacogenomics.
Clinical Application and Educational Training for Pharmacogenomics.
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DOI：
10.3390/pharmacy8030163
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发表时间：
2020-09-03
期刊：
影响因子：
--
通讯作者：
Oestreich JH
中科院分区：
文献类型：
--
作者：
Guy JW;Patel I;Oestreich JH
药物基因组学——被定义为研究基因如何影响一个人对药物的反应——在临床护理中越来越重要。许多药物都有与药物基因组学和患者护理相关的证据和药物标签。新的证据支持在临床环境中使用药物基因组学，基因检测可以优化药物选择和剂量。尽管有这些优势，将药物基因组学整合到临床决策中，在某些实践环境中仍然是可变的和具有挑战性的。为了确保跨环境的一致应用，有必要对当前和未来的医疗保健提供者进行充分的教育，以进一步将药物基因组学整合到常规临床实践中。这篇综述强调了目前支持药物基因组学标签临床应用的证据。第二个目标是审查目前教育保健专业人员和学员的战略。一个全国性组织预测，在美国的大部分地区将很快包含至少一个医疗保健系统能够应用药物基因组学信息。将基因型指导给药应用于几种fda批准的药物可能有助于对患者的预后产生有益的改变。确定教育卫生保健专业人员和受训人员的最佳做法对于药物基因组学服务的持续增长至关重要。随着药物基因组学继续扩展到更多的医疗保健领域，当前和未来的从业人员必须追求和保持药物基因组学的能力，以确保为患者提供更好的结果。
Pharmacogenomics—defined as the study of how genes affect a person’s response to drugs—is growing in importance for clinical care. Many medications have evidence and drug labeling related to pharmacogenomics and patient care. New evidence supports the use of pharmacogenomics in clinical settings, and genetic testing may optimize medication selection and dosing. Despite these advantages, the integration of pharmacogenomics into clinical decisions remains variable and challenging in certain practice settings. To ensure consistent application across settings, sufficient education amongst current and future healthcare providers is necessary to further integrate pharmacogenomics into routine clinical practice. This review highlights current evidence supporting clinical application of medications with pharmacogenomic labeling. The secondary objective is to review current strategies for educating health professionals and student trainees. One national organization predicts that most regions in the United States will soon contain at least one healthcare system capable of applying pharmacogenomic information. Applying genotype-guided dosing to several FDA-approved medications may help produce beneficial changes in patient outcomes. Identifying best practices for educating health care professionals and trainees remains vitally important for continuing growth of pharmacogenomic services. As pharmacogenomics continues to expand into more areas of healthcare, current and future practitioners must pursue and maintain competence in pharmacogenomics to ensure better outcomes for patients.
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