Linking Innate and Adaptive Immunity: Human Vγ9Vδ2 T Cells Enhance CD40 Expression and HMGB-1 Secretion
Linking Innate and Adaptive Immunity: Human Vγ9Vδ2 T Cells Enhance CD40 Expression and HMGB-1 Secretion
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DOI：
10.1155/2009/819408
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发表时间：
2009-01-01
影响因子：
4.6
通讯作者：
Chow, Anthony W.
中科院分区：
文献类型：
--
作者：
Kalyan, Shirin;Chow, Anthony W.
γ δ T细胞在调节对应激刺激的免疫应答中起重要作用;然而，这些先天性淋巴细胞实现该功能的方式仍然不清楚。人外周血γ δ T细胞的主要亚群响应于非肽抗原，例如异戊基焦磷酸（IPP），其是真核细胞和原核细胞的甲羟戊酸途径中的代谢物。IPP致敏的γ δ T细胞显著增强单核细胞和α β T细胞介导的对TSST-1的炎症反应，TSST-1是葡萄球菌超抗原，是中毒性休克综合征的主要病原体。在这里，我们表明，激活的外周γ δ T细胞的小池诱导单核细胞上的CD 40的早期上调和高迁移率族蛋白-1（HMGB-1）的局部释放，该分子被指定为全身炎症的晚期介质。这一发现为γ δ T细胞如何作为内源性和外源性应激刺激的有影响力的调节剂提供了新的基础。版权所有（C）2009 S. Kalyan和A. W.周梁淑
gamma delta T cells play an important role in regulating the immune response to stress stimuli; however, the mean by which these innate lymphocytes fulfill this function remains poorly defined. The main subset of human peripheral blood gamma delta T cells responds to nonpeptidic antigens, such as isopentylpyrophosphate (IPP), a metabolite in the mevalonate pathway for both eukaryote and prokaryote cells. IPP-primed gamma delta T cells significantly augment the inflammatory response mediated by monocytes and alpha beta T cells to TSST-1, the staphylococcal superantigen that is the major causative agent of toxic shock syndrome. Here we show that the small pool of activated peripheral gamma delta T cells induces an early upregulation of CD40 on monocytes and the local release of High Mobility Group Box-1 (HMGB-1), the molecule designated as the late mediator of systemic inflammation. This finding provides a new basis for how gamma delta T cells may serve as influential modulators of both endogenous and exogenous stress stimuli. Copyright (C) 2009 S. Kalyan and A. W. Chow.