Hedgehog Signaling in the Maintenance of Cancer Stem Cells.
Hedgehog Signaling in the Maintenance of Cancer Stem Cells.
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DOI：
10.3390/cancers7030851
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发表时间：
2015-08-11
期刊：
影响因子：
5.2
通讯作者：
Cain JE
中科院分区：
文献类型：
--
作者：
Cochrane CR;Szczepny A;Watkins DN;Cain JE
癌症干细胞（CSC）代表了一种罕见的细胞群体，具有自我更新的能力，并在肿瘤中产生异质细胞谱系。虽然CSC的调节机制尚不清楚，但正常干细胞和祖细胞功能所需的关键发育信号通路已被强烈暗示。Hedgehog（Hh）信号通路是一条进化上保守的信号通路，对细胞的自我更新和命运决定至关重要。异常的Hh信号传导与各种类型的癌症的发展和进展相关，并且涉及肿瘤发生的多个方面，包括CSC的维持。在这里，我们讨论了越来越多的证据表明，在血液系统恶性肿瘤和实体瘤的背景下，Hh驱动的CSC和新的策略，有可能阻止许多方面的转化归因于CSC表型，包括化疗耐药性，复发和转移。
Cancer stem cells (CSCs) represent a rare population of cells with the capacity to self-renew and give rise to heterogeneous cell lineages within a tumour. Whilst the mechanisms underlying the regulation of CSCs are poorly defined, key developmental signaling pathways required for normal stem and progenitor functions have been strongly implicated. Hedgehog (Hh) signaling is an evolutionarily-conserved pathway essential for self-renewal and cell fate determination. Aberrant Hh signaling is associated with the development and progression of various types of cancer and is implicated in multiple aspects of tumourigenesis, including the maintenance of CSCs. Here, we discuss the mounting evidence suggestive of Hh-driven CSCs in the context of haematological malignancies and solid tumours and the novel strategies that hold the potential to block many aspects of the transformation attributed to the CSC phenotype, including chemotherapeutic resistance, relapse and metastasis.