Emerging biomimetic nanotechnology in orthopedic diseases: progress, challenges, and opportunities
Emerging biomimetic nanotechnology in orthopedic diseases: progress, challenges, and opportunities
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DOI：
10.1016/j.trechm.2022.02.002
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发表时间：
2022-03
影响因子：
15.7
通讯作者：
Zhongyang Zhang;Jun Zhou;Chuang Liu;Jiaming Zhang;Yoshifuru Shibata;Na Kong;C. Corbo;Mitchel B. Harris;Wei Tao
中科院分区：
文献类型：
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作者：
Zhongyang Zhang;Jun Zhou;Chuang Liu;Jiaming Zhang;Yoshifuru Shibata;Na Kong;C. Corbo;Mitchel B. Harris;Wei Tao
骨科疾病（例如，骨折、骨肿瘤、骨关节炎、骨质疏松症、慢性炎症和感染）可导致运动残疾、丧失对其它软组织/器官的保护或造血、矿物质稳态和其它功能的功能障碍。仿生纳米技术的发展促进了骨科治疗的创新，以恢复天然骨组织的结构、组成和生物生理功能。明确其发病机制和了解疾病的发展过程，有助于设计和优化针对性的治疗方案。在此，我们总结了仿生纳米技术如何更有效地治疗各种骨科疾病的指南。我们还讨论了未满足的需求和当前的挑战，可能会阻碍仿生纳米技术为基础的骨科治疗的临床实施。
Orthopedic diseases (e.g., fracture, bone tumor, osteoarthritis, osteoporosis, chronic inflammation, and infection) can result in locomotion disability, loss of protection for other soft tissues/organs, or dysfunction of hematopoiesis, mineral homeostasis, and other functions. The development of biomimetic nanotechnology has advanced the innovation of orthopedic therapies for restoring the structure, composition, and biophysiological functions of the natural bone tissue. Identification of the pathogenesis and understanding the disease progression can greatly benefit the design and optimization of disease-specific therapy. Herein, we summarize guidelines on how biomimetic nanotechnology can be utilized in more efficiently treating various orthopedic diseases. We also discuss unmet needs and current challenges that might hinder the clinical implementation of biomimetic nanotechnology-based orthopedic therapies.