Anemia is an Independent Predictor of Long-Term Adverse Outcomes in Patients Hospitalized With Heart Failure in Japan
Anemia is an Independent Predictor of Long-Term Adverse Outcomes in Patients Hospitalized With Heart Failure in Japan
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贫血是日本心力衰竭住院患者长期不良结果的独立预测因素
DOI：
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发表时间：
2009
期刊：
影响因子：
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通讯作者：
H. Tsutsui
中科院分区：
文献类型：
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作者：
Sanae Hamaguchi;Miyuki Tsuchihashi;S. Kinugawa;T. Yokota;A. Takeshita;H. Yokoshiki;H. Tsutsui
背景：贫血在心力衰竭（HF）患者中很常见，并与不良结局相关。然而，在日本常规临床实践中遇到的HF患者中，贫血的影响尚不清楚。贫血对长期预后的影响，包括HF住院患者的死亡率和再住院率，因此进行了评估。方法与结果：日本心脏病学心力衰竭登记研究（JCARE-CARD）前瞻性研究了因HF恶化住院的广泛患者样本的特征和治疗，并随访了结局。研究队列（n= 1，960）按出院血红蛋白四分位数分为4组：<10.1 g/dl（n=482）、10.1-11.9 g/dl（n=479）、12.0-13.6 g/dl（n=487）和≥13.7 g/dl（n=512）。在HF患者的总队列中，57%患有贫血，使用世界卫生组织定义。血红蛋白四分位数较低的患者全因死亡、心源性死亡和因HF恶化而再次住院的发生率较高。多变量校正后，低血红蛋白浓度患者全因死亡、心源性死亡和再住院的风险显著增加。结论：贫血在日本的常规临床实践中相当常见，尤其是在HF患者中，较低的血红蛋白与这些患者的长期不良结局独立相关。(Circ J 2009; 73：1901-1908）
Background: Anemia is common in patients with heart failure (HF) and is associated with worse outcomes. However, the effects of anemia are unknown in an unselected group of HF patients encountered in routine clinical practice in Japan. The impact of anemia on long-term outcomes including mortality and rehospitalization among patients hospitalized with HF was thus assessed. Methods and Results: The Japanese Cardiac Registry of Heart Failure in Cardiology (JCARE-CARD) prospectively studied the characteristics and treatments in a broad sample of patients hospitalized with worsening HF and the outcomes were followed. Study cohorts (n=1,960) were classified into 4 groups by discharge hemoglobin quartiles: <10.1 g/dl (n=482), 10.1-11.9 g/dl (n=479), 12.0-13.6 g/dl (n=487), and ≥13.7 g/dl (n=512). Of the total cohort of HF patients, 57% had anemia, defined by using the World Health Organization definition. Patients with lower hemoglobin quartiles had higher rates of all-cause death, cardiac death, and rehospitalization due to worsening HF. After multivariable adjustment, the risk for all-cause death, cardiac death, and rehospitalization significantly increased with low hemoglobin concentrations. Conclusions: Anemia was quite common especially in patients with HF encountered in routine clinical practice in Japan, and lower hemoglobin was independently associated with long-term adverse outcomes in these patients. (Circ J 2009; 73: 1901-1908)
DOI：
10.1016/s0735-1097(01)01470-x
发表时间：
2001-10-01
影响因子：
24
作者：
Al-Ahmad, A;Rand, WM;Sarnak, MJ
通讯作者：
Sarnak, MJ