EXPRESSION OF METASTATIC POTENTIAL OF TUMOR-CELLS IN YOUNG NUDE-MICE IS CORRELATED WITH LOW-LEVELS OF NATURAL-KILLER CELL-MEDIATED CYTO-TOXICITY
EXPRESSION OF METASTATIC POTENTIAL OF TUMOR-CELLS IN YOUNG NUDE-MICE IS CORRELATED WITH LOW-LEVELS OF NATURAL-KILLER CELL-MEDIATED CYTO-TOXICITY
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DOI：
10.1002/ijc.2910260521
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发表时间：
1980-01-01
影响因子：
6.4
通讯作者：
HANNA, N
中科院分区：
文献类型：
--
作者：
HANNA, N
静脉注射 6 周和 3 周龄裸鼠注射具有明确转移特性的小鼠肿瘤细胞后，只有 3 周龄的小鼠出现了大量的肺肿瘤集落。静脉注射后，注射到同基因受体中的肿瘤细胞系之间的转移潜力的数量差异得以维持。注射到幼年裸鼠体内。 3周龄裸鼠的成功转移与这些年轻受体中检测到的低水平自然杀伤细胞活性相关。通过给予细菌佐剂和干扰素诱导剂来增强3周龄裸鼠的自然杀伤细胞活性，显着抑制转移形成。转移发展的差异不能归因于肺血管床中肿瘤细胞最初停滞的差异，而是归因于与6周龄裸鼠相比，3周龄裸鼠肺中停滞细胞的存活率更高。低水平的 NK（自然杀伤）细胞活性与实验性转移发生率增加有关。
Of 6 and 3 wk old nude mice given i.v. injections of murine tumor cells with well-defined metastatic properties, only the 3 wk old mice developed lung tumor colonies in significant numbers. The quantitative differences in metastatic potential among tumor cell lines injected into syngeneic recipients were maintained following i.v. injection into young nude mice. Successful metastasis in 3 wk old nude mice is correlated with the low levels of natural killer cell activity detected in these young recipients. Boosting of the natural killer cell activity of 3 wk old nude mice by the administration of bacterial adjuvants and interferon inducers significantly inhibited metastasis formation. The differences in metastasis development could not be attributed to differences in the initial arrest of tumor cells in the pulmonary vascular bed but rather to a better survival of the arrested cells in the lungs of 3 wk old nude mice as compared with 6 wk old counterparts. Low levels of NK [natural killer] cell activity are associated with increased incidence of experimental metastasis.