Detection of Macular Function Changes in Early (AREDS 2) and Intermediate (AREDS 3) Age-Related Macular Degeneration
Detection of Macular Function Changes in Early (AREDS 2) and Intermediate (AREDS 3) Age-Related Macular Degeneration
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DOI：
10.1159/000320340
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发表时间：
2011-01-01
期刊：
影响因子：
2.6
通讯作者：
Casciano, Margherita
中科院分区：
文献类型：
--
作者：
Vujosevic, Stela;Smolek, Michael K.;Casciano, Margherita
背景/目的：评价使用专用（筛查）设备获得的视网膜敏感度值是否可用于功能性识别早期和中期年龄相关性黄斑变性（ARMD）。研究方法：全自动眼底视野计结合图像稳定扫描激光检眼镜被用于5个研究中心的200例ARMD患者（319只眼）。年龄匹配的对照组由200名正常人组成。记录敏感点值（S值）、平均视网膜敏感度、低于24 dB的点数（K值，正常值的截止值）和固视稳定性。结果：319眼中，早期ARMD（AREDS 2级）164眼，中期ARMD（AREDS 3级）155眼。平均视网膜敏感度在ARMD患者中与正常人相比显著降低（p < 0.001）。正常人与ARMD患者之间的K值有差异（p < 0.001）。早期和中期ARMD患者的固定稳定性没有差异。结论：与年龄匹配的正常人相比，早期和中期ARMD患者的黄斑敏感性降低。这些变化可以用筛选设备检测到。版权所有（C）2010 S. Karger AG，巴塞尔
Background/Aim:To evaluate if retinal sensitivity values obtained with a dedicated (screening) device can be used to functionally identify early and intermediate age-related macular degeneration (ARMD). Methods: A fully automatic fundus perimeter combined with an image-stabilized scanning laser ophthalmoscope was used in 200 ARMD patients (319 eyes) in 5 study sites. The age-matched control group consisted of 200 normals. Sensitivity point values (S values), mean retinal sensitivity, number of points below 24 dB (K value, cutoff for normal values) and fixation stability were recorded. Results: Of 319 eyes, 164 were classified as early (AREDS 2) and 155 as intermediate (AREDS 3) ARMD. Mean retinal sensitivity was significantly reduced in ARMD patients versus normals (p < 0.001). K values were different between normals and ARMD patients (p < 0.001). Fixation stability did not differ between early and intermediate ARMD patients. Conclusions: Macular sensitivity is reduced in pa-tients with early and intermediate ARMD when compared to age-matched normals. These changes may be detected with a screening device. Copyright (C) 2010 S. Karger AG, Basel