Cellular and molecular pathways linking inflammation and cancer
Cellular and molecular pathways linking inflammation and cancer
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DOI：
10.1016/j.imbio.2009.06.014
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发表时间：
2009-09-01
期刊：
影响因子：
2.8
通讯作者：
Sica, Antonio
中科院分区：
文献类型：
--
作者：
Porta, Chiara;Larghi, Paola;Sica, Antonio
一些实验和流行病学证据表明，无论发展的诱因是什么(慢性感染/炎症或基因改变)，“阴燃”的炎症与大多数(如果不是全部)肿瘤有关，并支持肿瘤的进展。一些证据强调，肿瘤促进粒-单核细胞的持续流入，这些细胞表达支持肿瘤前功能的炎症介质。粒单核细胞是癌症相关炎症的主要协调者，与恶性肿瘤细胞的增殖和存活、适应性免疫反应的颠覆、血管生成、间质重塑和转移形成有关。尽管炎症与癌症之间的联系是明确的，但这种联系的机制基础很大程度上是未知的。本文讨论了肿瘤相关炎症的细胞和分子途径及其作为诊断、预后和治疗靶点的潜在相关性的最新进展。(C)2009年爱思唯尔股份有限公司。版权所有。
Several experimental and epidemiological evidence indicate that, irrespective of the trigger for the development (chronic infection/inflammation or genetic alteration), a "smouldering" inflammation is associated with the most of, if not all, tumours and supports their progression.Several evidence have highlighted that tumours promote a constant influx of myelomonocytic cells that express inflammatory mediators supporting pro-tumoral functions. Myelomonocytic cells are key orchestrators of cancer-related inflammation associated with proliferation and survival of malignant cells, Subversion of adaptive immune response, angiogenesis, stroma remodelling and metastasis formation.Although the connection between inflammation and cancer is unequivocal the mechanistic basis of such association are largely unknown. Recent advances in the understanding of the cellular and molecular pathways involved in cancer-related inflammation as well as their potential relevance as diagnostic, prognostic and therapeutic targets are herein discussed. (C) 2009 Elsevier GmbH. All rights reserved.