Plasma Levels of Matrix Metalloproteinase-9: A Possible Diagnostic Marker of Successful Endovascular Aneurysm Repair
Plasma Levels of Matrix Metalloproteinase-9: A Possible Diagnostic Marker of Successful Endovascular Aneurysm Repair
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DOI：
10.1016/j.ejvs.2011.10.014
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发表时间：
2012-02-01
影响因子：
5.7
通讯作者：
Schurink, G. W. H.
中科院分区：
文献类型：
--
作者：
Hellenthal, F. A. M. V. I.;Ten Bosch, J. A.;Schurink, G. W. H.
目的：探讨血浆基质金属蛋白酶-2和-9及其组织抑制物-1(TIMP-1)对血管内动脉瘤修补术(EVAR)后内漏的诊断价值。在内漏患者中观察到基质金属蛋白酶-9水平升高(P<；0.001)。回归分析显示年龄、性别和腹主动脉瘤(AAA)大小没有显著影响。血浆基质金属蛋白酶-9水平的受试者工作特征曲线显示，以55.18ngml(-1)为临界值，诊断内漏的灵敏度和特异度分别为100%和96%，AUC值为0.988(P<；0.001)。结论：血浆基质金属蛋白酶-9水平可以区分有无内漏的患者，具有较高的敏感性和特异性。(C)2011年欧洲血管外科学会。爱思唯尔有限公司出版。保留所有权利。
Objective: The aim of the study was evaluating the diagnostic value of plasma matrix metalloproteinase-(MMP)-2 and -9 and tissue inhibitor of MMP-1 (TIMP-1) for endoleak detection after endovascular aneurysm repair (EVAR).Report: Consecutive EVAR patients (n = 17) with endoleak and matched controls without endoleak (n = 20) were prospectively enrolled. Increased levels of MMP-9 were observed in patients with endoleak (P < 0.001). Regression analysis showed no significant influence of age, sex or abdominal aortic aneurysm (AAA) size. The receiver operating characteristic (ROC) curve of plasma MMP-9 levels showed that a cutoff value of 55.18 ng ml(-1) resulted in 100% sensitivity and 96% specificity with an AUC value of 0.988 (P < 0.001) to detect endoleak.Conclusions: Plasma MMP-9 levels appear to discriminate between patients with and without an endoleak with high sensitivity and specificity. (C) 2011 European Society for Vascular Surgery. Published by Elsevier Ltd. All rights reserved.